Prostaglandin E1 Impurity 4 Chemical Properties

Melting point:

77-79 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3))

Boiling point:

529.3±50.0 °C(Predicted)

Density 

1.131±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: >100 mg/ml (from PGE1); DMSO: >50 mg/ml (from PGE1); Ethanol: >50 mg/ml (from PGE1); PBS pH 7.2: >1.6 mg/ml (from PGE1)

form 

A light yellow crystalline solid

pka

4.77±0.10(Predicted)

Prostaglandin E1 Impurity 4 Usage And Synthesis

Description

Isoprostanes are a family of prostanoid molecules of non-cyclooxygenase origin. 8-iso Prostaglandin E₁ (8-iso PGE₁) is an isoprostane which is found in human semen at levels of 7 μg/ml. It is a pulmonary vasoconstrictor in anesthetized dogs with a potency similar to PGF_2α.

Uses

Isoprostanes are a family of prostanoid molecules of non-cyclooxygenase origin. 8-iso Prostaglandin E1 (8-iso PGE1) is an isoprostane which is found in human semen at levels of 7 μg/ml. It is a pulmonary vasoconstrictor in anesthetized dogs with a potency similar to PGF2α.[Cayman Chemical]

Uses

8-Isoprostaglandin E1 has vasodilatory and electrophysiological actions porcine coronary artery. It also inhibits acetylcholine release from parasympathetic nerves innervating guinea-pig trachea mediation by prostanoid EP3 receptors.

Definition

ChEBI: 8-Isoprostaglandin E1 is a prostanoid.

References

[1] J D MORROW. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1990, 87 23: 9383-9387. DOI: 10.1073/pnas.87.23.9383
[2] TAYLOR P L. The 8-isoprostaglandins: Evidence for eight compounds in human semen[J]. Prostaglandins, 1979, 17 2: Pages 259-267. DOI: 10.1016/0090-6980(79)90046-7
[3] J NAKANO  J M K. Effects of 8-isoprostaglandin E1 on the systemic and pulmonary circulations in dogs.[J]. Proceedings of the Society for Experimental Biology and Medicine, 1970, 133 4: 1314-1317. DOI: 10.3181/00379727-133-34679
[4] CATHERINE A. OPERE. Dual Effect of Isoprostanes on the Release of [3H]D-Aspartate from Isolated Bovine Retinae: Role of Arachidonic Acid Metabolites[J]. Neurochemical Research, 2005, 30 1: 129-137. DOI: 10.1007/s11064-004-9694-3

Prostaglandin E1 Impurity 4(21003-46-3)Related Product Information

• Prostaglandin E1 Impurity 4
• Isoprostane Related Compound 1
• PROSTAGLANDIN A2
• 8-ISOPROSTANE
• PROSTAGLANDIN A1
• 6-KETO-PROSTAGLANDIN F1ALPHA
• Prostaglandin E1 Impurity 2
• 15-KETO PROSTAGLANDIN E1
• 15(R)-PROSTAGLANDIN E1
• 15(R)-PROSTAGLANDIN E2
• 11BETA-PROSTAGLANDIN E2
• Prostaglandin E1
• PROSTAGLANDIN H2
• Prostaglandin E2
• Undecenoic acid
• 10TR-PENTADECENOIC ACID
• 8-ISO PROSTAGLANDIN E1
• TRANS-13-OCTADECENOIC ACID