N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea CAS#: 1057249-41-8

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea Basic information

Product Name:

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea

Synonyms:

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea
SNS-314
1-(3-chlorophenyl)-3-(4-(2-(thieno[3,2-d]pyriMidin-4-ylaMino)ethyl)thiazol-2-yl)urea
SNS314;SNS 314
CS-901
Urea, N-(3-chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]-
1-(3-chlorophenyl)-3-(5-(2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl)thiazol-2-yl)urea
SNS-314 free base

CAS:

1057249-41-8

MF:

C18H15ClN6OS2

MW:

430.93

Product Categories:

api

Mol File:

1057249-41-8.mol

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N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea Chemical Properties

Density: 1.588
storage temp.: Store at -20°C
solubility: DMSO: 100 mg/mL (232.06 mM);Ethanol: Insoluble
pka: 6.12±0.70(Predicted)
Water Solubility: Water: Insoluble
InChI: InChI=1S/C18H15ClN6OS2/c19-11-2-1-3-12(8-11)24-17(26)25-18-21-9-13(28-18)4-6-20-16-15-14(5-7-27-15)22-10-23-16/h1-3,5,7-10H,4,6H2,(H,20,22,23)(H2,21,24,25,26)
InChIKey: FAYAUAZLLLJJGH-UHFFFAOYSA-N
SMILES: N(C1=CC=CC(Cl)=C1)C(NC1=NC=C(CCNC2N=CN=C3C=CSC3=2)S1)=O

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N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]urea Usage And Synthesis

Uses

SNS-314 is used in the synthesis of AuroraA kinase inhibitors used in cancer treatment.

Definition

ChEBI: 1-(3-chlorophenyl)-3-[5-[2-(4-thieno[3,2-d]pyrimidinylamino)ethyl]-2-thiazolyl]urea is a member of ureas.

in vivo

In the HCT116 human colon cancer xenograft model, administration of 50 and 100 mg/kg SNS-314 leads to dose-dependent inhibition of histone H3 phosphorylation for at least 10 h. SNS-314 shows significant tumor growth inhibition in a dose dependent manner under a variety of dosing schedules including weekly, bi-weekly, and 5 days on/9 days off^[2].

IC 50

Aurora A: 9 nM (IC₅₀); Aurora B: 31 nM (IC₅₀); Aurora C: 6 nM (IC₅₀)

N-(3-Chlorophenyl)-N'-[5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-2-thiazolyl]ureaSupplier

Shanghai Dongyang Biotechnology Co., Ltd. Gold

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com

Shanghai Boyle Chemical Co., Ltd.

Tel
Email: sales@boylechem.com

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Email: jkinfo@jkchemical.com

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Email: sales@BioChemBest.com

SYN|thesis med chem P/L

Tel: +86-021-50720296
Email: service@synkinase.com

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