TDZD-8 Chemical Properties

Melting point:

63-64.4 °C

storage temp. 

2-8°C

solubility 

DMSO: 18 mg/mL

form 

needles

color 

white

Safety Information

Hazard Codes 

Xi

Risk Statements 

43

Safety Statements 

36/37

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

TDZD-8 Usage And Synthesis

Uses

A thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3

Uses

Glycogen Synthase Kinase-3? is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. TDZD-8 is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK-3? ( IC50 =2nM). Binds to the active site of GSK-3?. Does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM).

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