4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- CAS#: 314771-88-5

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- Basic information

Product Name:

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-

Synonyms:

7-((S)-tetrahydrofuran-3-yloxy)-4-(3-chloro-4-fluorophenyl)aMino-6-nitroquinazoline
N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinaMine
Afatinib intermediate C
4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-
(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-aMine
N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-
N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]
N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-4-amine

CAS:

314771-88-5

MF:

C18H14ClFN4O4

MW:

404.78

EINECS:

925-395-5

Product Categories:

Afatinib Dimaleate

Mol File:

314771-88-5.mol

More

Less

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- Chemical Properties

Boiling point:: 585.0±50.0 °C(Predicted)
Density: 1.534±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 5.07±0.70(Predicted)

More

Less

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]- Usage And Synthesis

Uses

(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib (A355305) which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

4-QuinazolinaMine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-Supplier

Arizest(Shanghai)Pharmatech Co.,Ltd Gold

Tel: 60753300-53010 13671599112
Email: geshi.zhuang@acebright.com

BeiJing Hwrk Chemicals Limted

Tel: 0757-86329057 18934348241
Email: sales4.gd@hwrkchemical.com

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Email: chenyj@titansci.com

Shanghai Feibo Chemical Technology Co., Ltd

Tel: 021-58955608,2250286 15921236618
Email: blinkzeng@gmail.com

Synches Co., Ltd.

Tel: 021-53292253
Email: biz@synches.com

More

Less