(S)-(+)-3-Hydroxytetrahydrofuran
(S)-(+)-3-Hydroxytetrahydrofuran Basic information
- Product Name:
- (S)-(+)-3-Hydroxytetrahydrofuran
- Synonyms:
-
- (S)-TETRAHYDROFURAN-3-OL
- (S)-(+)-TETRAHYDRO-3-FURANOL
- (S)-(+)-3-HYDROXY TETAHYDRO FURAN
- (S)-(-)-3-HYDROXY TETRAHYDRO FURAN
- (3S)-oxolan-3-ol
- (2S)-1,4-Epoxy-2-hydroxybutane, (3S)-Tetrahydrofuran-3-ol, (3S)-Oxolan-3-ol
- Afatinib intermediate B
- (S)-(+)-3-Hydroxytetrahydrofuran, ee: 95%
- CAS:
- 86087-23-2
- MF:
- C4H8O2
- MW:
- 88.11
- EINECS:
- 425-090-2
- Product Categories:
-
- Afatinib intermediate
- Chiral Building Blocks
- Chiral Reagents
- Furans
- Simple Alcohols (Chiral)
- Synthetic Organic Chemistry
- Alcohols, Hydroxy Esters and Derivatives
- Chiral Compounds
- Starting Raw Materials & Intermediates
- Small molecule
- Tetrahydrofuran Series
- bc0001
- 86087-23-2
- john's
- ADVANCED INT.
- 1
- Mol File:
- 86087-23-2.mol
(S)-(+)-3-Hydroxytetrahydrofuran Chemical Properties
- Boiling point:
- 80 °C/15 mmHg (lit.)
- alpha
- 18.5 º (c=2 MeOH)
- Density
- 1.103 g/mL at 25 °C (lit.)
- vapor pressure
- 47Pa at 25℃
- refractive index
- n20/D 1.45(lit.)
- Flash point:
- 175 °F
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Chloroform, Methanol (Slightly)
- pka
- 14.49±0.20(Predicted)
- form
- Liquid
- Specific Gravity
- 1.11
- color
- Clear colorless to pale yellow
- optical activity
- [α]20/D +17.5°, c = 2.4 in methanol
- Water Solubility
- soluble
- BRN
- 4652609
- Stability:
- Stable. Combustible. Incompatible with strong oxidizing agents.
- InChIKey
- XDPCNPCKDGQBAN-BYPYZUCNSA-N
- LogP
- -0.784 at 22℃ and pH6.8
- Surface tension
- 72mN/m at 1g/L and 25℃
- CAS DataBase Reference
- 86087-23-2(CAS DataBase Reference)
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
(S)-(+)-3-Hydroxytetrahydrofuran Usage And Synthesis
Description
(S)-(+)-3-Hydroxytetrahydrofuran (3-OH THF) is a colorless liquid with a normal boiling point of 179 °C and boiling at 88-89 °C at 17 mmHg, with density (1.087 g/cm3 at 19 °C). 3-OH THF is a useful pharmaceutical intermediate. The chiral (absolute configuration S) version of this compound is an intermediate to launched retroviral drugs.
Chemical Properties
Colourless Liquid
Uses
(S)-(+)-3-Hydroxytetrahydrofuran is a useful reagent for the preparation of pyrazolo triazin ylamine derivatives as adenosine receptor antagonists.
Uses
(S)-(+)-3-Hydroxytetrahydrofuran is an intermediate to the AIDS drugs amprenavir and fosamprenavir. Additionally, it has been an intermediate to developmental drug substances, such as chemotherapy agents.
Synthesis
(S)-(+)-3-Hydroxytetrahydrofuran was prepared from the reaction of (S)-1,2,4-butanetriol under hydrochloric acid modified montmorillonite catalyst. The steps were as follows:To the heatable reactor (with stirring device), 100g (S)-1,2,4-butanetriol, 200mL toluene, 15g hydrochloric acid modified montmorillonite catalyst prepared in were added successively. The reaction was stopped after 4 h at 110°C. After the reaction is finished, it is naturally cooled to room temperature, and the obtained material is filtered to recover the catalyst. After collecting the filtrate, the remaining solvent and by-product water in the filtrate are distilled off to obtain (S)-3-hydroxytetrahydrofuran crude product. Quantitative analysis was carried out by gas chromatography, and the yield was 96.8%. Finally, the (S)-3-hydroxytetrahydrofuran was obtained by rectification and purification.
(S)-(+)-3-Hydroxytetrahydrofuran Preparation Products And Raw materials
Raw materials
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(S)-(+)-3-Hydroxytetrahydrofuran(86087-23-2)Related Product Information
- Tetrahydrofuran
- 2-Methyltetrahydrofuran
- 3-(S)-HYDROXY TETRAHYDROFURAN
- 3-HYDROXYTETRAHYDROFURAN 99%,3-HYDROXYTETRAHYDROFURAN
- (RS)-3-Hydroxytetrahydrofuran
- POLY(TETRAHYDROFURAN) STANDARD 15000
- (R)-(+)-3-HYDROXYTETRAHYDROFURAN-2-ONE
- α-D-erythro-Pentofuranose-2-deoxy-2,2-difluoro-3,5-dibenzoate
- (S)-4-HYDROXYTETRAHYDROFURAN-2-ONE,4(S)-Hydroxytetrahydrofuran-2-ONE
- 3-HYDROXYTETRAHYDROFURAN-2-ONE,2-Hydroxytetrahydrofuran-2-one
- (R)-(-)-3-HYDROXYTETRAHYDROFURAN,(R)-3-HYDROXYTETRAHYDROFURAN
- ((2R,3S,5R)-5-(5-(3-Aminopropyl)-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxytetrahydrofuran-2-yl)methyl tetrahydrogen triphosphate
- (S)-(+)-3-HYDROXYTETRAHYDROFURAN-D4
- (3R)-3β,4α-Bis(3-methoxy-4-hydroxybenzyl)-3-hydroxytetrahydrofuran-2-one
- (2R, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL
- (2R, 4R)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL
- (2S, 4S)-4-HYDROXYTETRAHYDROFURAN-2-METHANOL
- 4-HYDROXYTETRAHYDROFURAN-2-METHANOL