3-Hydroxytetrahydrofuran Chemical Properties

Melting point:

25°C

Boiling point:

181 °C (lit.)

Density 

1.09 g/mL at 25 °C (lit.)

vapor pressure 

760 mm Hg ( 181 °C)

refractive index 

n20/D 1.45(lit.)

Flash point:

178 °F

storage temp. 

Sealed in dry,Room Temperature

pka

14.49±0.20(Predicted)

form 

Liquid

color 

Clear colorless to yellow

Specific Gravity

1.090

Water Solubility 

500g/L(room temperature)

Stability:

Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides.

InChIKey

XDPCNPCKDGQBAN-UHFFFAOYSA-N

LogP

-0.830 (est)

CAS DataBase Reference

453-20-3(CAS DataBase Reference)

NIST Chemistry Reference

Tetrahydrofuran, 3-hydroxy-(453-20-3)

EPA Substance Registry System

3-Furanol, tetrahydro- (453-20-3)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38-19

Safety Statements 

26-36-37/39

WGK Germany 

3

RTECS 

LU3450050

HS Code 

29321900

MSDS

• Language:English Provider:3-Hydroxytetrahydrofuran
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

3-Hydroxytetrahydrofuran Usage And Synthesis

Chemical Properties

light yellow liquid

Synthesis

The general procedure for the synthesis of 3-hydroxytetrahydrofuran from 1,2,4-butanetriol is as follows: 1,2,4-butanetriol is mixed with an equal volume of dioxane as a solvent in a batch reactor and a strongly acidic ion-exchange resin containing sulfonic acid groups (Amberlyst 15, in the H+ form) is added as a catalyst. The reaction was carried out at 100 °C for 20 h at atmospheric pressure. Upon completion of the reaction, the yield of 3-hydroxytetrahydrofuran was 96 mol%.

References

[1] Patent: WO2005/121111, 2005, A1. Location in patent: Page/Page column 33
[2] Patent: WO2005/121111, 2005, A1. Location in patent: Page/Page column 33
[3] Patent: WO2007/81065, 2007, A1. Location in patent: Page/Page column 6
[4] Patent: WO2005/121111, 2005, A1. Location in patent: Page/Page column 31; 34
[5] Patent: WO2005/121111, 2005, A1. Location in patent: Page/Page column 33-34

3-Hydroxytetrahydrofuran(453-20-3)Related Product Information

• 2-Methyltetrahydrofuran
• Tetrahydrofuran
• POLY(TETRAHYDROFURAN) STANDARD 15000
• (S)-(+)-3-Hydroxytetrahydrofuran
• α-Chloralose
• 1,2:3,5-Di-O-isopropylidene-alpha-D-xylofuranose
• beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate
• D-(-)-PANTOLACTONE
• 8-BROMOADENOSINE
• beta-D-Ribofuranose 1,2,3,5-tetraacetate
• D-GLUCOHEPTONO-1,4-LACTONE
• 2,2'-Cyclouridine
• D-RIBULOSE
• Span 60
• DIACETONE-D-GLUCOSE
• Span 20
• D-(-)-Gulonic acid gamma-lactone
• D-SACCHARIC ACID 1,4-LACTONE