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4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-

Basic information Safety Supplier Related

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Basic information

Product Name:
4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-
Synonyms:
  • 4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-
  • N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine
  • 4-(3-chloro-4-fiuoro-phen...
  • 4-(3-chloro-4-fiuoro-phenylaMino)-7-fluoro-6-nitroquninazoline
  • N-(3-chloro-4-fluorophenyl)-N-(7-fluoro-6-nitroquinazolin-4-yl)acetaMide
  • (3-Chloro-4-fluorophenyl)(7-fluoro-6-nitroquinazolin-4-yl)amine
  • N-(3-Chloro-4-fluorophenyl)-7-fluoro-6-nitro-4-quinazolinamine
  • Afatinib intermediate A
CAS:
162012-67-1
MF:
C14H7ClF2N4O2
MW:
336.68
EINECS:
000-000-0
Product Categories:
  • API intermediates
  • 162012-67-1
Mol File:
162012-67-1.mol
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4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Chemical Properties

Melting point:
242-244℃
Boiling point:
489℃
Density 
1.616
Flash point:
249℃
storage temp. 
2-8°C(protect from light)
solubility 
DMSO (Slightly), Methanol (Slightly, Sonicated)
form 
Solid
pka
5.07±0.70(Predicted)
color 
Yellow to Dark Yellow
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Safety Information

HS Code 
2933.59.8000
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4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro- Usage And Synthesis

Uses

4-(3-Chloro-4-fluorophenylamino)-7-fluoro-6-nitroquninazoline is an intermediate in the synthesis of Afatinib (A355300), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitro-Supplier

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