Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Basic information
- Product Name:
- Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
- Synonyms:
-
- Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
- 3-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenol
- Janex 3
- 3-(6,7-dimethoxyquinazolin-4-ylamino)phenol
- 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference)
- WHI P180;JANEX3;WHIP180;JANEX-3
- WHI-P180(Janex 3)
- WHI-P180, >98%
- CAS:
- 211555-08-7
- MF:
- C16H15N3O3
- MW:
- 297.31
- Product Categories:
-
- Inhibitors
- Mol File:
- 211555-08-7.mol
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Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Chemical Properties
- Boiling point:
- 476.5±40.0 °C(Predicted)
- Density
- 1.336±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C(protect from light)
- solubility
- DMSO : 25 mg/mL (84.09 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
- form
- Powder
- pka
- 9.58±0.10(Predicted)
- color
- White to off-white
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Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Usage And Synthesis
Biological Activity
WHI-P180 is an inhibitor of multiple kinases with IC50 values of 4.5 nM and 66 nM for RET (c-RET) and KDR, respectively.
in vivo
WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following iv, ip, or po administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic ip bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.
target
Target | Value |
RET (Cell-free assay) | 4.5 nM |
KDR (Cell-free assay) | 66 nM |
Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-Supplier
Dalian Meilun Biotech Co., Ltd.
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
- Tel
- 025-66099280 17798518460
- cfzhang@aikonchem.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
MedChemexpress LLC
- Tel
- 021-58955995
- sales@medchemexpress.cn
Nanjing Chalf-Pharm Technology Co., Ltd.
- Tel
- 025-57018978 18251899859
- sales@chalf-pharm.com
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Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-(211555-08-7)Related Product Information
- 4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL
- WEHI-345
- JAK3 INHIBITOR II
- JAK3 INHIBITOR I
- 4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE
- WH-4-023
- 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
- 3,4-Dimethoxyphenethylamine
- 2-Methylsulfonyl-4,6-dimethoxypyrimidine
- WHI-P97
- 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE
- JAK3 Inhibitor