Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- CAS#: 211555-08-7

Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Basic information

Product Name:

Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-

Synonyms:

Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-
3-[(6,7-Dimethoxy-4-quinazolinyl)amino]phenol
Janex 3
3-(6,7-dimethoxyquinazolin-4-ylamino)phenol
3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol (Related Reference)
WHI P180;JANEX3;WHIP180;JANEX-3
WHI-P180(Janex 3)
WHI-P180, >98%

CAS:

211555-08-7

MF:

C16H15N3O3

MW:

297.31

Product Categories:

Inhibitors

Mol File:

211555-08-7.mol

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Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Chemical Properties

Boiling point:: 476.5±40.0 °C(Predicted)
Density: 1.336±0.06 g/cm3(Predicted)
storage temp.: 2-8°C(protect from light)
solubility: DMSO : 25 mg/mL (84.09 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
pka: 9.58±0.10(Predicted)

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Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]- Usage And Synthesis

Biological Activity

WHI-P180 is an inhibitor of multiple kinases with IC50 values of 4.5 nM and 66 nM for RET (c-RET) and KDR, respectively.

in vivo

WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses. The elimination half-life of WHI-P180 in CD-1 mice (BALB/c mice) following iv, ip, or po administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-I mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic ip bolus doses of 25 mg/kg, inhibits IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis.

target

Target	Value
RET (Cell-free assay)	4.5 nM
KDR (Cell-free assay)	66 nM

Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-Supplier

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com

Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66099280 17798518460
Email: cfzhang@aikonchem.com

Haoyuan Chemexpress Co., Ltd.

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MedChemexpress LLC

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Nanjing Chalf-Pharm Technology Co., Ltd.

Tel: 025-57018978 18251899859
Email: sales@chalf-pharm.com

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