4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Chemical Properties

Boiling point:

441.2±40.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml

form 

A crystalline solid

pka

6.19±0.70(Predicted)

color 

White to off-white

4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Usage And Synthesis

Description

WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated K_i value of 72 μM. However, it is inactive at JAK3 (IC₅₀ = >300 μM) and has been used as a negative control for structurally similar compounds that inhibit platelet aggregation and herpes simplex virus 1 (HSV-1) replication.

Uses

4-Phenylamino-6,7-dimethoxyquinazoline is a specific inhibitors of Janus kinase 3 (JAK3).

References

[1] E A SUDBECK. Structure-based design of specific inhibitors of Janus kinase 3 as apoptosis-inducing antileukemic agents.[J]. Clinical Cancer Research, 1999, 5 6: 1569-1582.
[2] SHIN-ICHI YOKOTA . Induction of suppressor of cytokine signaling-3 by herpes simplex virus type 1 confers efficient viral replication[J]. Virology, 2005, 338 1: Pages 173-181. DOI: 10.1016/j.virol.2005.04.028
[3] H. TIBBLES. Role of a JAK3-dependent Biochemical Signaling Pathway in Platelet Activation and Aggregation*[J]. The Journal of Biological Chemistry, 2001, 25 1: 17815-17822. DOI: 10.1074/jbc.m011405200

4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE(21561-09-1)Related Product Information

• 4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL
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