4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Chemical Properties

Boiling point:

441.2±40.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml

form 

A crystalline solid

pka

6.19±0.70(Predicted)

color 

White to off-white

4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE Usage And Synthesis

Description

WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated K_i value of 72 μM. However, it is inactive at JAK3 (IC₅₀ = >300 μM) and has been used as a negative control for structurally similar compounds that inhibit platelet aggregation and herpes simplex virus 1 (HSV-1) replication.

Uses

4-Phenylamino-6,7-dimethoxyquinazoline is a specific inhibitors of Janus kinase 3 (JAK3).

4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE(21561-09-1)Related Product Information

• 4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL
• WEHI-345
• JAK3 INHIBITOR I
• 4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE
• WH-4-023
• 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE
• WHI-P97
• JAK3 Inhibitor
• Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-