Basic information Safety Supplier Related

JAK3 INHIBITOR I

Basic information Safety Supplier Related

JAK3 INHIBITOR I Basic information

Product Name:
JAK3 INHIBITOR I
Synonyms:
  • 4-(4'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE
  • JAK3 INHIBITOR I
  • WHI-P131
  • Janex 1
  • A JAK3 inhibitor WHI-P131
  • 4-(6,7-dimethoxyquinazolin-4-ylamino)phenol
  • WHI-P131(Janex 1)
  • JANEX-1;WHI-P131
CAS:
202475-60-3
MF:
C16H15N3O3
MW:
297.31
Product Categories:
  • Inhibitors
  • Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
Mol File:
202475-60-3.mol
More
Less

JAK3 INHIBITOR I Chemical Properties

Boiling point:
468.1±40.0 °C(Predicted)
Density 
1.336±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO: 18 mg/mL, soluble
form 
solid
pka
10.06±0.26(Predicted)
color 
yellow
Stability:
Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20°C for up to 2 months.
More
Less

Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
More
Less

JAK3 INHIBITOR I Usage And Synthesis

Description

WHI-P131 (202475-60-3) is a JAK3 inhibitor.?Inhibits human glioblastoma cell adhesion and invasion.1 Increases survival in a mouse ALS model.2 Delays or prevents autoimmune type 1 diabetes in NOD mice.3 Exhibits potent anti-inflammatory activity in mouse models of peritonitis, colitis, cellulitis and systemic inflammatory response syndrome.4 Displays protective effects against myocardial ischemia and reperfusion injury in mouse models.5

Uses

Janex 1 is a Janus tyrosine kinase 3 (JAK3) inhibitor. Inhibition of JAK3 has been shown to exhibit protective action against the development of T1D in non-obese diabetic (NOD) mice. Janex 1 has been shown to suppresses proliferation of short-term cultured NOD CD4+ T cells through induction of apoptosis, while promoting survival of a particular population of long-term cultured cells. It ameliorates the expression of TNF-α-induced cell adhesion molecules and improves myocardial vascular permeability.

References

1) Narla et al. (1998), Inhibition of human glioblastoma cell adhesion and invasion by 4-(4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3’-bromo-4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154); Mol. Clin. Cancer Res., 4 2463 2) Trieu et al. (2000), A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis; Biochem. Biophys. Res. Commun., 267 22 3) Cetkovic-Cvrlje et al. (2003), Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice; Clin. Immunol., 106 213 4) Uckun et al. (2008), Anti-inflammatory activity profile of JANEX-1 in preclinical animal models; Bioorg. Med. Chem., 16 1287 5) Oh et al. (2013), Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice; Exp. Mol. Med., 45 e23

JAK3 INHIBITOR ISupplier

Angel Pharmatech, Ltd. Gold
Tel
17317130613
Email
3358272972@qq.com
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
China Langchem Inc.
Tel
0086-21-58956006
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Email
info@chemexpress.com
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Email
market@aladdin-e.com