JAK3 INHIBITOR I
JAK3 INHIBITOR I Basic information
- Product Name:
- JAK3 INHIBITOR I
- Synonyms:
-
- 4-(4'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE
- JAK3 INHIBITOR I
- WHI-P131
- Janex 1
- A JAK3 inhibitor WHI-P131
- 4-(6,7-dimethoxyquinazolin-4-ylamino)phenol
- WHI-P131(Janex 1)
- JANEX-1;WHI-P131
- CAS:
- 202475-60-3
- MF:
- C16H15N3O3
- MW:
- 297.31
- Product Categories:
-
- Inhibitors
- Heterocycles, Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals
- Mol File:
- 202475-60-3.mol
JAK3 INHIBITOR I Chemical Properties
- Boiling point:
- 468.1±40.0 °C(Predicted)
- Density
- 1.336±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- DMSO: 18 mg/mL, soluble
- form
- solid
- pka
- 10.06±0.26(Predicted)
- color
- yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20°C for up to 2 months.
JAK3 INHIBITOR I Usage And Synthesis
Description
WHI-P131 (202475-60-3) is a JAK3 inhibitor.?Inhibits human glioblastoma cell adhesion and invasion.1 Increases survival in a mouse ALS model.2 Delays or prevents autoimmune type 1 diabetes in NOD mice.3 Exhibits potent anti-inflammatory activity in mouse models of peritonitis, colitis, cellulitis and systemic inflammatory response syndrome.4 Displays protective effects against myocardial ischemia and reperfusion injury in mouse models.5
Uses
Janex 1 is a Janus tyrosine kinase 3 (JAK3) inhibitor. Inhibition of JAK3 has been shown to exhibit protective action against the development of T1D in non-obese diabetic (NOD) mice. Janex 1 has been shown to suppresses proliferation of short-term cultured NOD CD4+ T cells through induction of apoptosis, while promoting survival of a particular population of long-term cultured cells. It ameliorates the expression of TNF-α-induced cell adhesion molecules and improves myocardial vascular permeability.
References
1) Narla et al. (1998), Inhibition of human glioblastoma cell adhesion and invasion by 4-(4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3’-bromo-4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154); Mol. Clin. Cancer Res., 4 2463 2) Trieu et al. (2000), A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis; Biochem. Biophys. Res. Commun., 267 22 3) Cetkovic-Cvrlje et al. (2003), Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice; Clin. Immunol., 106 213 4) Uckun et al. (2008), Anti-inflammatory activity profile of JANEX-1 in preclinical animal models; Bioorg. Med. Chem., 16 1287 5) Oh et al. (2013), Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice; Exp. Mol. Med., 45 e23
JAK3 INHIBITOR ISupplier
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- 010-82848833 400-666-7788
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- 0086-21-58956006
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- 021-58950125
- info@chemexpress.com
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- 400-400-6206333 18521732826
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JAK3 INHIBITOR I(202475-60-3)Related Product Information
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