Ethyl 1-Boc-3-pyrrolidinecarboxylate Chemical Properties

Boiling point:

305.6±35.0 °C(Predicted)

Density 

1.100±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

form 

solid

pka

-2.57±0.40(Predicted)

Appearance

Colorless to light yellow Liquid

CAS DataBase Reference

170844-49-2(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

26-36/37/39

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

2933998090

Ethyl 1-Boc-3-pyrrolidinecarboxylate Usage And Synthesis

Synthesis

A dichloromethane (50 mL) solution of di-tert-butyl dicarbonate (10.30 g, 47.2 mmol) was slowly added dropwise to a dichloromethane (50 mL) solution of crude ethyl 3-pyrrolidinecarboxylate (7.12 g) at 0 °C for a controlled time of 10 min or more. The reaction mixture was gradually warmed up to room temperature over 18 h. The mixture was washed with water and saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford ethyl N-Boc-3-pyrrolidinecarboxylate (10.4 g, 100% yield), which could be used for the subsequent reaction without further purification.1H NMR (CDCl3) δ: 4.14 (q, 2H), 3.27-3.69 (m , 4H), 3.02 (m, 1H), 2.07-2.16 (m, 2H), 1.46 (s, 9H), 1.27 (t, 3H).

References

[1] Patent: WO2005/49602, 2005, A1. Location in patent: Page/Page column 89; 90; 130
[2] Patent: WO2005/49605, 2005, A1. Location in patent: Page/Page column 117; 118; 158

Ethyl 1-Boc-3-pyrrolidinecarboxylate(170844-49-2)Related Product Information

• Ethyl acrylate
• Ethanol
• Ethyl formate
• Ethyl acetate
• Ethyl cyanoacetate
• BUTYL OLEATE
• 3-Pyrrolidinecarboxylic acid
• OXALIC ACID
• Tris(trimethylsilyl)phosphate
• Crospovidone
• Polyvinylpyrrolidone
• ISOXADIFEN-ETHYL
• Sodium L-pyroglutamate
• Pyrrolidine
• Ethylparaben
• Butyl acetate
• Trinexapac-ethyl
• N-Methyl-2-pyrrolidone