COCHLIOQUINONE A Chemical Properties

Melting point:

135 °C

Boiling point:

638.8±55.0 °C(Predicted)

Density 

1.21±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble

form 

A yellow lyophilisate

pka

11.57±0.70(Predicted)

Safety Information

HS Code 

2933399990

COCHLIOQUINONE A Usage And Synthesis

Uses

Cochlioquinone A is the major component of a bioactive pigment isolated from Bipolaris leersia. Cochlioquinone A has recently been shown to be an antagonist of the human chemokine receptor, CCR5, in HIV-1,). Cochlioquinone A is anti-angiogenic and exhibits inhibitory activity against diacylglycerol acyltransferase and NADH-ubiquinone reductase.

Uses

Cochlioquinone A, a bioactive compound isolated from D. sacchari and Bipolaris sp., is an inhibitor of diacylglycerol kinase (DGK; Ki = 3.1 μM) and diacylglycerol acyltransferase (DGAT; IC50 = 5.6 μM). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma with an IC50 value of 3 μM. It is also reported to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors with an IC50 value of 11 μM.[Cayman Chemical]

Uses

Cochlioquinone A is an antagonist of CCR5. Diacylglycerol kinase inhibitor.

Definition

ChEBI: Cochlioquinone A is a member of oxanes.

COCHLIOQUINONE A(32450-25-2)Related Product Information

• COCHLIOQUINONE B
• 4-(2,2,6-TRIMETHYLCYCLOHEXYL)-2-BUTANONE
• THYMOQUINONE
• GAMMA-TERPINENE
• CYCLOHEXYL VINYL ETHER
• COCHLIOQUINONE A