Tr-PEG7-alcohol Chemical Properties

Boiling point:

630.1±50.0 °C(Predicted)

Density 

1.124±0.06 g/cm3(Predicted)

solubility 

Soluble in DMSO, DCM, DMF

pka

14.36±0.10(Predicted)

Tr-PEG7-alcohol Usage And Synthesis

Description

Tr-PEG7 is a PEG linker containing a trityl alcohol protecting group. The trityl group can be removed under acidic conditions or through hydrogenolysis. The hydrophilic PEG linker increases the water solubility properties of compounds. Increasing the number of ethylene glycol units within a PEG chain improves their water solubility properties.

Uses

Tr-PEG6-OH is a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

References

[1] Subhadip Senapati, et al. A Y-Shaped Three-Arm Structure for Probing Bivalent Interactions between Protein Receptor–Ligand Using AFM and SPR. Langmuir. 2018 May.

Tr-PEG7-alcohol(127999-16-0)Related Product Information

• Tr-PEG9
• 2,5,8,11-Tetraoxatridecan-13-ol, 1,1,1-triphenyl-
• Ethanol, 2-[2-[2-(triphenylmethoxy)ethoxy]ethoxy]-
• Tr-PEG6
• Tr-PEG3
• Rosin