2,5,8,11-Tetraoxatridecan-13-ol, 1,1,1-triphenyl-
2,5,8,11-Tetraoxatridecan-13-ol, 1,1,1-triphenyl- Basic information
- Product Name:
- 2,5,8,11-Tetraoxatridecan-13-ol, 1,1,1-triphenyl-
- Synonyms:
-
- 2,5,8,11-Tetraoxatridecan-13-ol, 1,1,1-triphenyl-
- Tr-PEG5
- 1,1,1-triphenyl-2,5,8,11-tetraoxatridecan-13-ol
- 1,1,1-triphenyl-2,5,8,11-tetraoxatridecan-13-ol(WXPC0040)
- 3,6,9,12-Tetraoxatridecan-1-ol, 13,13,13-triphenyl-
- 2-[2-[2-(2-trityloxyethoxy)ethoxy]ethoxy]ethanol
- Trt-PEG4-OH
- CAS:
- 125274-16-0
- MF:
- C27H32O5
- MW:
- 436.54
- Mol File:
- 125274-16-0.mol
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2,5,8,11-Tetraoxatridecan-13-ol, 1,1,1-triphenyl- Chemical Properties
- storage temp.
- Storage temp. 2-8°C
- form
- Liquid
- color
- Colorless to light yellow
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2,5,8,11-Tetraoxatridecan-13-ol, 1,1,1-triphenyl- Usage And Synthesis
Description
Tr-PEG5 is a PEG linker containing a trityl, alcohol protecting group and a terminal hydroxyl group. Trityl can be removed under acidic conditions. The hydroxyl group can undergo various reactions in order to further derivatize the compound. The hydrophilic PEG linkers increase the solubility of compounds in aqueous media.
Uses
Tr-PEG4-OH is a non-cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
References
[1] Zhang Q, et al. Synthesis of a library of propargylated and PEGylated α-hydroxy acids toward "clickable" polylactides via hydrolysis of cyanohydrin derivatives. J Org Chem. 2014 Oct 17;79(20):9546-55. DOI:10.1021/jo5016135
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