Tr-PEG6 Chemical Properties

Boiling point:

595.6±45.0 °C(Predicted)

Density 

1.125±0.06 g/cm3(Predicted)

pka

14.36±0.10(Predicted)

Tr-PEG6 Usage And Synthesis

Description

Tr-PEG6 is a trityl ether protected PEG chain. The trityl ether can be removed under mildly acidic conditions or via hydrogenolysis. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media.

Uses

Tr-PEG5-OH is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tr-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.

IC 50

Non-cleavable Linker; PEGs

References

[1] Branderhorst HM, et al. Strong inhibition of cholera toxin binding by galactose dendrimers. Chem Commun (Camb). 2007 Dec 21;(47):5043-5. DOI:10.1039/b711070g
[2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

Tr-PEG6(141282-24-8)Related Product Information

• Tr-PEG9
• 2,5,8,11-Tetraoxatridecan-13-ol, 1,1,1-triphenyl-
• Ethanol, 2-[2-[2-(triphenylmethoxy)ethoxy]ethoxy]-
• Tr-PEG7-alcohol
• Tr-PEG3