Acid-PEG4-S-PEG4-Acid Chemical Properties

Boiling point:

658.3±55.0 °C(Predicted)

Density 

1.190±0.06 g/cm3(Predicted)

pka

3.97±0.10(Predicted)

Acid-PEG4-S-PEG4-Acid Usage And Synthesis

Description

Acid-PEG4-S-PEG4-acid contains two terminal carboxylic acid groups. The carboxylic acid groups can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic PEG chains increase the water solubility of the compound in aqueous media.

Uses

Acid-PEG4-S-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Acid-PEG4-S-PEG4-Acid(2055041-21-7)Related Product Information

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