Acid-PEG4-Sulfone-PEG4-Acid Chemical Properties

Boiling point:

729.4±60.0 °C(Predicted)

Density 

1.242±0.06 g/cm3(Predicted)

pka

3.97±0.10(Predicted)

Acid-PEG4-Sulfone-PEG4-Acid Usage And Synthesis

Description

Acid-PEG4-Sulfone-PEG4-acid contains two PEG-acid chains connected by a sulfone group. The sulfone group can be conjugated with thiol groups of proteins. The terminal carboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic PEG spacer increases the water solubility of the compound in aqueous media.

Uses

Sulfone-Bis-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

Acid-PEG4-Sulfone-PEG4-Acid(2055024-37-6)Related Product Information

• alpha, oMega-Dipropionic acid triethylene glycol
• α,ω-dipropionic acid tetraethylene glycol
• NSC 361680
• Acid-PEG25-NHS ester
• Acid-PEG5-t-butyl ester
• Acid-PEG3-mono-methyl ester
• Acid-PEG5-NHS ester
• Acid-PEG4-mono-methyl ester
• Acid-PEG4-t-butyl ester
• Acid-PEG4-S-PEG4-Acid