NSC 361680 Chemical Properties

Melting point:

60-61 °C

Boiling point:

198-200 °C(Press: 1-2 Torr)

Density 

1.316±0.06 g/cm3(Predicted)

storage temp. 

-20°C Freezer, Under inert atmosphere

solubility 

Aqueous Base (Slightly), Chloroform (Slightly), Methanol (Slightly), Water (Slightly)

form 

Solid

pka

3.96±0.10(Predicted)

color 

Pale Yellow to Light Yellow

NSC 361680 Usage And Synthesis

Description

Bis-PEG1-acid is a PEG linker containing two terminal carboxylic acid groups. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acids can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

Bis-PEG1-acid is a PEG-based PROTAC linker and can be used in the synthesis of PROTACs as BCL-xL degraders and anticancer agents with low platelet toxicity.

NSC 361680(5961-83-1)Related Product Information

• alpha, oMega-Dipropionic acid triethylene glycol
• α,ω-dipropionic acid tetraethylene glycol
• Acid-PEG4-Sulfone-PEG4-Acid
• Acid-PEG5-t-butyl ester