7,8-DIHYDRO-L-BIOPTERIN Chemical Properties

Melting point:

>300°C dec.

Boiling point:

470.8±55.0 °C(Predicted)

Density 

1.88

storage temp. 

Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility 

Aqueous Acid (Slightly, Sonicated), Aqueous Base (Slightly), DMSO (Slightly)

pka

10.47±0.20(Predicted)

form 

Solid

color 

Pale Yellow to Brown

BRN 

536551

Stability:

Hygroscopic

InChIKey

FEMXZDUTFRTWPE-AWFVSMACSA-N

CAS DataBase Reference

6779-87-9

Safety Information

WGK Germany 

3

F 

3-10

MSDS

• Language:English Provider:SigmaAldrich

7,8-DIHYDRO-L-BIOPTERIN Usage And Synthesis

Description

BH₂ is a precursor of BH₄ synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a K_i of 14.4 μM.

Chemical Properties

Yellow Powder

Uses

An oxidation producct of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of G

Uses

BH2 is a precursor of BH4 synthesis. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM.

Uses

The reduced form of Biopterin. An oxidation product of tetrahydrobiopterin, a naturally occurring cofactor of the aromatic amino acid hydroxylase and is involved in the synthesis of tyrosine and the neurotransmitters dopamine and serotonin. It is a noncompetitive inhibitor of GTP cyclohydrolase I, with a Ki of 14.4 μM.

Definition

ChEBI: L-erythro-7,8-dihydrobiopterin is a 7,8-dihydrobiopterin in which the 1,2-dihydroxypropyl group has (1R,2S)-configuration; naturally occurring form. It is an enantiomer of a D-erythro-7,8-dihydrobiopterin.

References

[1] shen r, alam a, zhang y. inhibition of gtp cyclohydrolase i by pterins[j]. biochimica et biophysica acta (bba)-general subjects, 1988, 965(1): 9-15.
[2] sugiyama t, levy b d, michel t. tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells[j]. journal of biological chemistry, 2009, 284(19): 12691-12700.

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