ChemicalBook > Product Catalog > Biochemical Engineering > Saccharides > Monosaccharide > 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil
1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil
1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil Basic information
- Product Name:
- 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil
- Synonyms:
-
- 2’-fluoro-5-ethyl-1-beta-d-arabinofuranosyluracil
- 1,3-Dimethyl-4-Amino-5-Formamide-Uracil FAU
- 1-(2'-Deoxy-2'-fluoro-b-D-arabinofuranosyl)uracil
- 1-[(2R,3S,4R,5R)-3-Fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
- 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-
- 2'-Fluoro-arabinofuranosyl-2'-deoxy-uridine
- 2'-Deoxy-2'-fluoro-beta-D-arabinouridine
- 2,4(1H,3H)-PyriMidinedione, 1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-
- CAS:
- 69123-94-0
- MF:
- C9H11FN2O5
- MW:
- 246.19
- Product Categories:
-
- Nucleosides-2'-FANA Nucleosides
- Mol File:
- 69123-94-0.mol
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1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil Chemical Properties
- Melting point:
- 162 °C(Solv: chloroform (67-66-3); methanol (67-56-1))
- Density
- 1.63±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Methanol: Soluble
- pka
- 9.39±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- InChI
- InChI=1/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6+,7-,8-/s3
- InChIKey
- UIYWFOZZIZEEKJ-QOUWCGOQNA-N
- SMILES
- [C@@H]1([C@@H](F)[C@H](O)[C@@H](CO)O1)N1C=CC(=O)NC1=O |&1:0,1,3,5,r|
- CAS DataBase Reference
- 69123-94-0
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1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil Usage And Synthesis
Chemical Properties
Colourless solid
Uses
1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
References
[1] Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. DOI:10.2174/138161212801227005
[2] KYOICHI A. WATANABE. Nucleosides. 110. Synthesis and antiherpes virus activity of some 2’-fluoro-2’-deoxyarabinofuranosylpyrimidine nucleosides[J]. Journal of Medicinal Chemistry, 1979, 22 1: 21-24. DOI: 10.1021/jm00187a005
1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracilSupplier
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- +86 (25) 82263158
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1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil(69123-94-0)Related Product Information
- CHLOROPHOSPHONAZO III
- Furazolidone
- Floxuridine
- Tetrahydrofuran
- Uracil
- Tris(hydroxymethyl)nitromethane
- Pyrimidine
- FURFURYL ALCOHOL RESIN
- Carbofuran
- Fialuridine
- Hydroxymethyl
- 2',2'-DIFLUORO-2'-DEOXYURIDINE
- 5-Trimethylstannyl-1-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil
- 2',2'-DIFLUORO-2'-DEOXYURIDINE 13C, 15N2
- 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)uracil
- 2'-FLUORO-2'-DEOXYARABINOFURANOSYL-URACIL, [5-3H]-
- 2'-FLUORO 2'-DEOXYURACIL-BETA-D-ARABINOFURANOSIDE, [2-14C]-
- 2'-FLUORO 2'-DEOXYURACIL-BETA-D-ARABINOFURANOSIDE, 5'-MONOPHOSPHATE, DITRIETHYLAMMONIUM SALT, [5-3H]-