2-Acetamidophenol
2-Acetamidophenol Basic information
- Product Name:
- 2-Acetamidophenol
- Synonyms:
-
- 2-ACETYLAMINOPHENOL
- 2-ACETAMIDOPHENOL
- 2-ACETAMINO PHENOL
- Acetaminophen Related Compound C (50 mg) (N-(2-hydroxyphenyl)acetamide)
- AKOS BBB/377
- O-HYDROXYACETANILIDE
- O-ACETAMIDOPHENOL
- O-ACETAMINOPHENOL
- CAS:
- 614-80-2
- MF:
- C8H9NO2
- MW:
- 151.16
- EINECS:
- 210-396-9
- Product Categories:
-
- Amines
- Aromatics
- Aromatic Phenols
- Phenol&Thiophenol&Mercaptan
- Anilines, Amides & Amines
- Phenols
- Mol File:
- 614-80-2.mol
2-Acetamidophenol Chemical Properties
- Melting point:
- 205-210 °C(lit.)
- Boiling point:
- 273.17°C (rough estimate)
- Density
- 1.2023 (rough estimate)
- refractive index
- 1.5810 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 9.35±0.35(Predicted)
- form
- Powder
- color
- Off-white to beige to brown
- BRN
- 607592
- Stability:
- Stable. Incompatible with strong oxidizing agents, chloroformates, acids, acid chlorides, acid anhydrides.
- InChI
- InChI=1S/C8H9NO2/c1-6(10)9-7-4-2-3-5-8(7)11/h2-5,11H,1H3,(H,9,10)
- InChIKey
- ADVGKWPZRIDURE-UHFFFAOYSA-N
- SMILES
- C(NC1=CC=CC=C1O)(=O)C
- CAS DataBase Reference
- 614-80-2(CAS DataBase Reference)
- NIST Chemistry Reference
- Acetamide, N-(2-hydroxyphenyl)-(614-80-2)
- EPA Substance Registry System
- 2'-Hydroxyacetanilide (614-80-2)
Safety Information
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/38-22-36/37/38
- Safety Statements
- 26-36-37/39
- RIDADR
- 2811
- WGK Germany
- 3
- RTECS
- AE4025000
- F
- 1-8
- TSCA
- Yes
- HazardClass
- 6.1(b)
- PackingGroup
- III
- HS Code
- 29242995
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
2-Acetamidophenol Usage And Synthesis
Chemical Properties
white or light brown powder.soluble in hot water and ethanol, slightly soluble in cold water.
Uses
An Acetaminophen (A161220) impurity.
2-Acetamidophenol is used as raw material to manufacture industrial organic chemicals.
Acetaminophen is an analgesic and antipyretic agent and used as a pain reliever to treat headache, muscle aches, and arthritis.
Definition
ChEBI: 2-acetamidophenol is a member of the class of phenols that is 2-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. A positional isomer of paracetamol which possesses anti-inflammatory, anti-arthritic and anti-platelet aggregation properties. It has a role as a platelet aggregation inhibitor, an anti-inflammatory agent, a xenobiotic metabolite, an apoptosis inducer, an antineoplastic agent and an antirheumatic drug. It is a member of phenols and a member of acetamides.
Preparation
Mix 2-Aminophenol , acetic acid and Acetic anhydride (i.e., crystals appear), and then directly heated on the fire until all dissolved, stop heating, cooling, water dilution, precipitation of crystals filtered dry, to 70-80 ℃ of ethanol recrystallization to obtain 2-acetamidophenol.
General Description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Purification Methods
Recrystallise it from water, EtOH or Est aqueous EtOH. [Beilstein 13 H 370, 13 I 113, 13 II 171, 13 III 778.]
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2-Acetamidophenol(614-80-2)Related Product Information
- 4'-Aminoacetanilide
- 4'-Nitroacetanilide
- Acetamide
- 4-Hydroxyaniline hydrochloride
- 3-Diethylaminophenol
- p-Acetotoluidide
- 2-BENZOYLACETANILIDE
- 2-ACETAMIDOFLUORENE
- 4-Aminophenol
- 2-Aminophenol
- 2-Chloro-4-acetamidophenol
- ACETAMINOPHEN IMPURITY B
- 4'-CHLOROACETANILIDE
- 4-[1-(hydroxyamino)ethylidene]cyclohexa-2,5-dien-1-one
- 4,4'-Iminodiphenol hydrochloride
- 4'-Hydroxyacetophenone
- 2'-Hydroxyacetophenone
- 4-Acetoxyacetanilide