2-Acetamidophenol Chemical Properties

Melting point:

205-210 °C(lit.)

Boiling point:

273.17°C (rough estimate)

Density 

1.2023 (rough estimate)

refractive index 

1.5810 (estimate)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Powder

pka

9.35±0.35(Predicted)

color 

Off-white to beige to brown

BRN 

607592

Stability:

Stable. Incompatible with strong oxidizing agents, chloroformates, acids, acid chlorides, acid anhydrides.

InChI

InChI=1S/C8H9NO2/c1-6(10)9-7-4-2-3-5-8(7)11/h2-5,11H,1H3,(H,9,10)

InChIKey

ADVGKWPZRIDURE-UHFFFAOYSA-N

SMILES

C(NC1=CC=CC=C1O)(=O)C

CAS DataBase Reference

614-80-2(CAS DataBase Reference)

NIST Chemistry Reference

Acetamide, N-(2-hydroxyphenyl)-(614-80-2)

EPA Substance Registry System

2'-Hydroxyacetanilide (614-80-2)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/38-22-36/37/38

Safety Statements 

26-36-37/39

RIDADR 

2811

WGK Germany 

3

RTECS 

AE4025000

F 

1-8

TSCA 

Yes

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29242995

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Acetamidophenol Usage And Synthesis

Chemical Properties

white or light brown powder.soluble in hot water and ethanol, slightly soluble in cold water.

Uses

An Acetaminophen (A161220) impurity.
2-Acetamidophenol is used as raw material to manufacture industrial organic chemicals.
Acetaminophen is an analgesic and antipyretic agent and used as a pain reliever to treat headache, muscle aches, and arthritis.

Definition

ChEBI: 2-acetamidophenol is a member of the class of phenols that is 2-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. A positional isomer of paracetamol which possesses anti-inflammatory, anti-arthritic and anti-platelet aggregation properties. It has a role as a platelet aggregation inhibitor, an anti-inflammatory agent, a xenobiotic metabolite, an apoptosis inducer, an antineoplastic agent and an antirheumatic drug. It is a member of phenols and a member of acetamides.

Preparation

Mix 2-Aminophenol , acetic acid and Acetic anhydride (i.e., crystals appear), and then directly heated on the fire until all dissolved, stop heating, cooling, water dilution, precipitation of crystals filtered dry, to 70-80 ℃ of ethanol recrystallization to obtain 2-acetamidophenol.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Purification Methods

Recrystallise it from water, EtOH or Est aqueous EtOH. [Beilstein 13 H 370, 13 I 113, 13 II 171, 13 III 778.]

2-Acetamidophenol(614-80-2)Related Product Information

• 4'-Aminoacetanilide
• 4'-Nitroacetanilide
• Acetamide
• 4-Hydroxyaniline hydrochloride
• 3-Diethylaminophenol
• p-Acetotoluidide
• 2-BENZOYLACETANILIDE
• 2-ACETAMIDOFLUORENE
• 4-Aminophenol
• 2-Aminophenol
• 2-Chloro-4-acetamidophenol
• ACETAMINOPHEN IMPURITY B
• 4'-CHLOROACETANILIDE
• 4-[1-(hydroxyamino)ethylidene]cyclohexa-2,5-dien-1-one
• 4,4'-Iminodiphenol hydrochloride
• 4'-Hydroxyacetophenone
• 2'-Hydroxyacetophenone
• 4-Acetoxyacetanilide