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2-Acetamidophenol

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2-Acetamidophenol Basic information

Product Name:
2-Acetamidophenol
Synonyms:
  • 2-ACETYLAMINOPHENOL
  • 2-ACETAMIDOPHENOL
  • 2-ACETAMINO PHENOL
  • Acetaminophen Related Compound C (50 mg) (N-(2-hydroxyphenyl)acetamide)
  • AKOS BBB/377
  • O-HYDROXYACETANILIDE
  • O-ACETAMIDOPHENOL
  • O-ACETAMINOPHENOL
CAS:
614-80-2
MF:
C8H9NO2
MW:
151.16
EINECS:
210-396-9
Product Categories:
  • Amines
  • Aromatics
  • Aromatic Phenols
  • Phenol&Thiophenol&Mercaptan
  • Anilines, Amides & Amines
  • Phenols
Mol File:
614-80-2.mol
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2-Acetamidophenol Chemical Properties

Melting point:
205-210 °C(lit.)
Boiling point:
273.17°C (rough estimate)
Density 
1.2023 (rough estimate)
refractive index 
1.5810 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
9.35±0.35(Predicted)
form 
Powder
color 
Off-white to beige to brown
BRN 
607592
Stability:
Stable. Incompatible with strong oxidizing agents, chloroformates, acids, acid chlorides, acid anhydrides.
InChI
InChI=1S/C8H9NO2/c1-6(10)9-7-4-2-3-5-8(7)11/h2-5,11H,1H3,(H,9,10)
InChIKey
ADVGKWPZRIDURE-UHFFFAOYSA-N
SMILES
C(NC1=CC=CC=C1O)(=O)C
CAS DataBase Reference
614-80-2(CAS DataBase Reference)
NIST Chemistry Reference
Acetamide, N-(2-hydroxyphenyl)-(614-80-2)
EPA Substance Registry System
2'-Hydroxyacetanilide (614-80-2)
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Safety Information

Hazard Codes 
Xi,Xn
Risk Statements 
36/38-22-36/37/38
Safety Statements 
26-36-37/39
RIDADR 
2811
WGK Germany 
3
RTECS 
AE4025000
1-8
TSCA 
Yes
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29242995

MSDS

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2-Acetamidophenol Usage And Synthesis

Chemical Properties

white or light brown powder.soluble in hot water and ethanol, slightly soluble in cold water.

Uses

An Acetaminophen (A161220) impurity.
2-Acetamidophenol is used as raw material to manufacture industrial organic chemicals.
Acetaminophen is an analgesic and antipyretic agent and used as a pain reliever to treat headache, muscle aches, and arthritis.

Definition

ChEBI: 2-acetamidophenol is a member of the class of phenols that is 2-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group. A positional isomer of paracetamol which possesses anti-inflammatory, anti-arthritic and anti-platelet aggregation properties. It has a role as a platelet aggregation inhibitor, an anti-inflammatory agent, a xenobiotic metabolite, an apoptosis inducer, an antineoplastic agent and an antirheumatic drug. It is a member of phenols and a member of acetamides.

Preparation

Mix 2-Aminophenol , acetic acid and Acetic anhydride (i.e., crystals appear), and then directly heated on the fire until all dissolved, stop heating, cooling, water dilution, precipitation of crystals filtered dry, to 70-80 ℃ of ethanol recrystallization to obtain 2-acetamidophenol.

General Description

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Purification Methods

Recrystallise it from water, EtOH or Est aqueous EtOH. [Beilstein 13 H 370, 13 I 113, 13 II 171, 13 III 778.]

2-Acetamidophenol Preparation Products And Raw materials

Raw materials

2-AcetamidophenolSupplier

Pushan Industry (Shaanxi) Co., Ltd. Gold
Tel
029-81310890 13571859809
Email
info@pushanshiye.com
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
Email
jkinfo@jkchemical.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
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021-61259108 18621169109
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market03@meryer.com
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Email
3bsc@sina.com
future industrial shanghai co., ltd
Tel
400-0066400 13621662912
Email
sales@jonln.com