Basic information Safety Supplier Related

TMS

Basic information Safety Supplier Related

TMS Basic information

Product Name:
TMS
Synonyms:
  • (E)-2,3',4,5'-TETRAMETHOXYSTILBENE
  • 2,3',4,5'-TETRAMETHOXYSTILBENE
  • 1-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXY-BENZENE
  • 1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE
  • 3,5,2’,4’-Tetramethoxystilbene
  • TMS - Trans-2,3',4,5'-tetramethoxystilbene
  • CS-961
  • Benzene, 1-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]-2,4-diMethoxy-
CAS:
24144-92-1
MF:
C18H20O4
MW:
300.35
Product Categories:
  • Antitumour
Mol File:
24144-92-1.mol
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TMS Chemical Properties

Melting point:
78-79 °C
Boiling point:
459.9±40.0 °C(Predicted)
Density 
1.117±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml
form 
Powder
color 
Light yellow to yellow
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TMS Usage And Synthesis

Uses

CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml.

Uses

2,4,3'',5''-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.

Uses

2,4,3',5'-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.

Definition

ChEBI: 1-[2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene is a stilbenoid.

Biological Activity

Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC 50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro .

TMSSupplier

Shanghai Boyle Chemical Co., Ltd.
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sales@boylechem.com
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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3bsc@sina.com
MedChemexpress LLC
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021-58955995
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AdooQ BioScience, LLC
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