TMS
TMS Basic information
- Product Name:
- TMS
- Synonyms:
-
- (E)-2,3',4,5'-TETRAMETHOXYSTILBENE
- 2,3',4,5'-TETRAMETHOXYSTILBENE
- 1-[(1E)-2-(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXY-BENZENE
- 1-[2,(3,5-DIMETHOXYPHENYL)ETHENYL]-2,4-DIMETHOXYBENZENE
- 3,5,2’,4’-Tetramethoxystilbene
- TMS - Trans-2,3',4,5'-tetramethoxystilbene
- CS-961
- Benzene, 1-[(1E)-2-(3,5-diMethoxyphenyl)ethenyl]-2,4-diMethoxy-
- CAS:
- 24144-92-1
- MF:
- C18H20O4
- MW:
- 300.35
- Product Categories:
-
- Antitumour
- Mol File:
- 24144-92-1.mol
TMS Chemical Properties
- Melting point:
- 78-79 °C
- Boiling point:
- 459.9±40.0 °C(Predicted)
- Density
- 1.117±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- solubility
- DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:1): 500 μg/ml; DMSO: 20 mg/ml; Ethanol: 400 μg/ml
- form
- Powder
- color
- Light yellow to yellow
TMS Usage And Synthesis
Uses
CYP1B1 is mainly an extrahepatic enzyme which oxidatively metabolizes both endogenous (steroids; eicosanoids) and exogenous xenobiotics such aspolyaromatic hydrocarbons. TMS is a potent and selective inhibitor of CYP1B1, with an IC50 of 6 nM. It is 50-fold selective for the inhibition of CYP1B1 versus CYP1A1, making it a useful tool to differentiate between various CYP450 families. In cultured human colon cancer cells, TMS induces apoptosis and inhibits cell growth with an IC50 of 0.8 μg/ml.
Uses
2,4,3'',5''-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.
Uses
2,4,3',5'-Tetramethoxystilbene acts as an inhibitor of human cytochrome P450 1B1 and has been seen to inhibit cell growth as well as induce apoptosis in cancer cells.
Definition
ChEBI: 1-[2-(2,4-dimethoxyphenyl)ethenyl]-3,5-dimethoxybenzene is a stilbenoid.
Biological Activity
Potent, selective and competitive inhibitor of cytochrome P450 1B1, an enzyme overexpressed in certain tumors (IC 50 = 6 nM). 50- and 520-fold selective over P450 1A1 and 1A2 respectively. Inhibits cancer cell growth in vitro .
TMSSupplier
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- sales@boylechem.com
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- 010-82848833 400-666-7788
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- 821-50328103-801 18930552037
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- 021-58955995
- sales@medchemexpress.cn
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- +1 (866) 930-6790
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TMS(24144-92-1)Related Product Information
- 4-NITROSTYRENE
- TOLUENE-D8, 99 ATOM % D (CONTAINS 1% V/V TMS)
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- Methanol-d4
- DIMETHYL SULFOXIDE-D6
- 1-TMS-1H-BENZOTRIAZOLE
- POLY(DIMETHYLSILOXANE-CO-METHYLHYDRO-SIL OXANE), TMS TERM, VISC CA. 260 CST
- Acetonitrile-d3
- Benzene-D6
- Tetrakis(trimethylsilyl)silane ((TMS)4Si )
- Pyridine-d5, contains 1 v/v% TMS, 99 atom % D, for NMR,Pyridine-d5, with 0.03% TMS, 100.0 atom% D, for NMR
- Chloroform-d
- ACETONE-D6
- TMS-BA [=N,O-BIS(TRIMETHYLSILYL)ACETAMIDE] 25% IN ACETONITRILE [FOR GAS CHROMATOGRAPHY]
- N,N-DIMETHYLFORMAMIDE-D7, 99.5 ATOM % D (CONTAINS 1% V/V TMS)
- 1-(TMS)ETHYNYLCYCLOHEXENE
- 1-TMS-1H-BENZOTRIAZOLE
- Cytochrome P450 1B1 Inhibitor, TMS