1-BROMO-2-BUTYNE Chemical Properties

Boiling point:

40-41 °C/20 mmHg (lit.)

Density 

1.519 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.508(lit.)

Flash point:

97 °F

storage temp. 

Inert atmosphere,Room Temperature

solubility 

Miscible with acetonitrile.

form 

Liquid

Specific Gravity

1.519

color 

Clear pale yellow-greenish

BRN 

605306

InChIKey

LNNXOEHOXSYWLD-UHFFFAOYSA-N

CAS DataBase Reference

3355-28-0(CAS DataBase Reference)

Safety Information

Risk Statements 

10

Safety Statements 

16-24/25

RIDADR 

UN 1993 3/PG 3

WGK Germany 

3

F 

10-23

HazardClass 

3

PackingGroup 

III

HS Code 

29033990

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-BROMO-2-BUTYNE Usage And Synthesis

Chemical Properties

Clear pale yellow-greenish liquid

Uses

1-Bromo-2-butyne is used in the preparation of six to eight annulated ring compounds in reaction with indoles and pseudopterane (+/-)-Kallolide B, which is a marine natural product. Further, it acts as a precursor in the preparation of axially chiral teranyl compounds, alkylation of L-tryptophan methyl ester, 4-butynyloxybenzene sulfonyl chloride and mono-propargylated diene derivative. In addition to this, it is also used in the synthesis of isopropylbut-2-ynylamine, allenylcyclobutanol derivatives, allyl-[4-(but-2-ynyloxy)phenyl]sulfane, allenylindium and axially chiral teranyl compounds.

Preparation

1-bromo-2-butyne is obtained by reacting 2-butyn-1-ol and organic solvent, pyridine.First react bromoethane with metal magnesium in THF to prepare Grignard reagent, then add paraformaldehyde to Grignard reagent for Grignard reaction, separate and recover after Grignard reaction 2-butyn-1-ol, then mix 2-butyn-1-ol with organic solvent and pyridine, add phosphorus tribromide dropwise for bromination reaction, separate and recover the product after bromination reaction.

General Description

1-Bromo-2-butyne is a propargyl bromide derivative. It is one of the constitutional isomer of bromo butyne. Its Br-loss threshold photoionization breakdown diagram has been analyzed to derive dissociative photoionization thresholds to C₄H₅⁺ production. It participates in the preparation of linagliptin.

1-BROMO-2-BUTYNE(3355-28-0)Related Product Information

• Levetiracetam
• Lercanidipine
• bamboo flavone
• Adapalene
• Rivaroxaban
• 2-Butyne
• 1-Bromo-3-butyne,4-BROMO-1-BUTYNE
• 1-Bromo-1-butyne
• 1-BROMO-2-BUTYNE
• 1-BROMO-2-PENTYNE
• 1,4-DIBROMO-2-BUTYNE
• 1-(3-BROMO-1-PROPYNYL)NAPHTHALENE
• 1-BROMO-2-OCTYNE
• 2-Bromo-3-Butyne
• 2-Methyl-4-bromo-3-butyne-2-ol
• 3-Bromo-1-butyne
• 2-BROMO-3-HEXYNE
• 1-(3-BROMOPROP-1-YNYL)-3,5-DI(TRIFLUOROMETHYL)BENZENE