2-Chloro-5-chloromethylthiazole Chemical Properties

Melting point:

31

Boiling point:

268.6±32.0 °C(Predicted)

Density 

1.503±0.06 g/cm3(Predicted)

refractive index 

n20/D1.571

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

soluble in Methanol

pka

0.19±0.10(Predicted)

color 

White to Light yellow

BRN 

5861439

InChI

InChI=1S/C4H3Cl2NS/c5-1-3-2-7-4(6)8-3/h2H,1H2

InChIKey

VRMUIVKEHJSADG-UHFFFAOYSA-N

SMILES

S1C(CCl)=CN=C1Cl

CAS DataBase Reference

105827-91-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,N,T

Risk Statements 

36/37/38-51/53-43-34-24-22

Safety Statements 

26-37-61-45-36/37/39

RIDADR 

2922

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

8

PackingGroup 

Ⅱ

HS Code 

29349990

2-Chloro-5-chloromethylthiazole Usage And Synthesis

Description

2-Chloro-5-chloromethylthiazole is used as pharmaceutical and agrochemical intermediate. It is also used as intermediate of insecticides Thiamethoxam and Clothianidin. It is also useful in in the synthesis of Ritonavir (R535000); a second-generation anti-AIDS drug and a selective HIV protease inhibitor.

Chemical Properties

White crystal or powder

Uses

2-Chloro-5-(chloromethyl)thiazole is a useful synthetic intermediate used in the synthesis of Ritonavir (R535000)

2-Chloro-5-chloromethylthiazole(105827-91-6)Related Product Information

• 4,6-Dichloropyrimidine
• 2-Chlorothiazole
• Chloromethane
• DIMETHYLTHEXYLSILYL CHLORIDE
• Metronidazole
• Dimethyl sulfone
• Nucleoside
• tert-Butyldimethylsilyl chloride
• 2-Methyl-4-isothiazolin-3-one
• 4-(Chloromethyl)benzoic acid
• Chloromethyl methyl ether
• Difluorochloromethane
• Thiamethoxam
• 5-Thiazolecarbonyl chloride, 2-chloro- (9CI)
• 5-CHLOROMETHYL-2,4-DICHLOROTHIAZOLE
• 2-Chloro-5-chloromethylthiazole
• 2-(4-BROMOPHENOXY)-4-CHLORO-5-CHLOROMETHYLTHIAZOLE
• 2-(3-CARBOXYPHENOXY)-4-CHLORO-5-CHLOROMETHYLTHIAZOLE