2-Chlorothiazole Chemical Properties

Melting point:

85 °C

Boiling point:

145 °C

Density 

1.393 g/mL at 25 °C

refractive index 

n20/D1.551

Flash point:

54℃

storage temp. 

Inert atmosphere,2-8°C

solubility 

soluble in Ether

form 

clear liquid

pka

0.84±0.10(Predicted)

color 

Colorless to Almost colorless

InChI

InChI=1S/C3H2ClNS/c4-3-5-1-2-6-3/h1-2H

InChIKey

KLEYVGWAORGTIT-UHFFFAOYSA-N

SMILES

S1C=CN=C1Cl

CAS DataBase Reference

3034-52-4(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

20/21/22-36/37/38-41-22-10

Safety Statements 

23-26-36/37/39-39

RIDADR 

1993

WGK Germany 

1

HazardClass 

3

PackingGroup 

Ⅲ

HS Code 

2934100090

MSDS

• Language:English Provider:ALFA

2-Chlorothiazole Usage And Synthesis

Application

2-Chlorothiazole is a pharmaceutical intermediate that can be prepared from 2-aminothiazole via a diazotization reaction. Literature reports that it can be used to prepare substituted tyrosine inhibitors containing zinc-binding genes, such as N-(2-chloro-6-methylphenyl)-2-(6-(4-(2-(hydroxyamino)-2-oxoethyl)piperidin-1-yl)-2-methylpyrimidin-4-ylamino)thiazole-5-carboxamide.

Chemical Properties

Pale yellow liquid

Definition

ChEBI: 2-chlorothiazole is a member of 1,3-thiazoles and an organochlorine compound.

Reactivity Profile

Halogen atoms in the 4- and 5-positions of thiazoles exhibit different reactivities depending on the nucleophile: with methoxide ion in methanol the reactivity sequence is 5-chlorothiazole > 2-chlorothiazole > 4-chlorothiazole. In contrast, with thiophenoxide ion or piperidine in methanol, the sequence 2 > 4 > 5 is observed. With the series of alkoxide ions methoxide, ethoxide, isopropoxide and t-butoxide in the corresponding alcohol, the reactivity ratios of 4-chlorothiazole versus 2-chlorothiazole are: 0.07, 0.6, 4, 42. The nucleophilic reactivity of 2-halogenothiazoles is strongly affected by substituents: 2-chloro-5-nitrothiazole is more reactive than 2-chlorothiazole by a factor of 10.

Synthesis

General procedure for the synthesis of 2-chlorothiazole from thiazole: To an anhydrous THF (60 mL) solution of thiazole (5.0 g, 58.7 mmol) was added n-butyllithium (1.6 M hexane solution, 44 mL, 70.4 mmol) slowly and dropwise over a period of 20 min at -78 °C with stirring. The reaction mixture was kept at 0 °C for 15 min, followed by dropwise addition of anhydrous THF (40 mL) solution of 2,2,2-trichloroacetyl chloride (6.6 mL, 58.7 mmol) to the orange colored mixture. The reaction mixture was continued to be stirred at -78 °C for 30 min, after which the reaction was quenched with saturated ammonium chloride solution (100 mL). After extraction with ether (2 x 150 mL), the organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (0-20% ether/pentane gradient elution) to afford the target compound 2-chlorothiazole (4.95 g, isolated yield 71%).1H NMR (400 MHz, CDCl3) δ 7.50 (d, J=4.0 Hz, 1H), 7.15 (d, J=4.0 Hz, 1H).

References

[1] Patent: WO2008/150446, 2008, A1. Location in patent: Page/Page column 29
[2] Journal of Organometallic Chemistry, 1999, vol. 588, # 2, p. 155 - 159
[3] Journal of Organometallic Chemistry, 2000, vol. 601, # 2, p. 233 - 236

2-Chlorothiazole(3034-52-4)Related Product Information

• Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT)
• Thiazole
• 2,2'-Dithiobis(benzothiazole)
• Fosthiazate
• Benzothiazole
• Epichlorohydrin
• 2-(2-Aminothiazol-4-yl)glyoxylic acid
• 2-Mercaptobenzothiazole
• 2-Chlorobenzothiazole
• Difluorochloromethane
• 2,6-Dichlorobenzothiazole
• 2-Chloro-6-nitrobenzothiazole
• 2-CHLORO-4-METHYL-THIAZOLE
• Benzothiazole, 2,5-dichloro- (7CI,8CI,9CI)
• 2,4-Dichlorobenzothiazole
• Chloroacetic acid
• 2-Chloro-6-methoxybenzothiazole
• 2,4-Dichloro-5-thiazolecarboxaldehyde