2-Chloro-5-chloromethylthiazole

Description

Product Name: 2-Chloro-5-chloromethylthiazole
CAS No.: 105827-91-6
Chemical Name: 2-Chloro-5-chloromethylthiazole
Synonyms: ccmt;2-CHLORO-5-CHLOROMETHYL-1,3-THIAZOLE;oro-5-(chL;2-Chloro-5-chl;2-Chloro-5-chloromet;2-Chloro-5-Chloromethyl;Clomethiazolum Impurity 4;2-CHLORO-5-CHLOROMETHYLTHIAZOLE;2-Chloro-5-chloromehtylthiazole;2-Chloro-5-(chlormethyl)thiazole
CBNumber: CB0366188
Molecular Formula: C4H3Cl2NS
Formula Weight: 168.04
MOL File: 105827-91-6.mol

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2-Chloro-5-chloromethylthiazole Property

Melting point:: 31
Boiling point:: 268.6±32.0 °C(Predicted)
Density: 1.503±0.06 g/cm3(Predicted)
refractive index: n20/D1.571
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: soluble in Methanol
pka: 0.19±0.10(Predicted)
color: White to Light yellow
BRN: 5861439
InChI: InChI=1S/C4H3Cl2NS/c5-1-3-2-7-4(6)8-3/h2H,1H2
InChIKey: VRMUIVKEHJSADG-UHFFFAOYSA-N
SMILES: S1C(CCl)=CN=C1Cl
CAS DataBase Reference: 105827-91-6(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,N,T
Risk Statements: 36/37/38-51/53-43-34-24-22
Safety Statements: 26-37-61-45-36/37/39
RIDADR: 2922
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 8
PackingGroup: Ⅱ
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H311Toxic in contact with skin

H314Causes severe skin burns and eye damage

H317May cause an allergic skin reaction

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3295
Product name: 2-Chloro-5-(chloromethyl)thiazole
Packaging: 5G
Price: $26
Updated: 2024/03/01

TCI Chemical

Product number: C3295
Product name: 2-Chloro-5-(chloromethyl)thiazole
Packaging: 25G
Price: $84
Updated: 2024/03/01

TRC

Product number: C367145
Product name: 2-Chloro-5-(chloromethyl)thiazole
Packaging: 5g
Price: $45
Updated: 2021/12/16

TRC

Product number: C367145
Product name: 2-Chloro-5-(chloromethyl)thiazole
Packaging: 25g
Price: $70
Updated: 2021/12/16

TRC

Product number: C367145
Product name: 2-Chloro-5-(chloromethyl)thiazole
Packaging: 50g
Price: $95
Updated: 2021/12/16

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2-Chloro-5-chloromethylthiazole Chemical Properties,Usage,Production

Description

2-Chloro-5-chloromethylthiazole is used as pharmaceutical and agrochemical intermediate. It is also used as intermediate of insecticides Thiamethoxam and Clothianidin. It is also useful in in the synthesis of Ritonavir (R535000); a second-generation anti-AIDS drug and a selective HIV protease inhibitor.

Chemical Properties

White crystal or powder

Uses

2-Chloro-5-(chloromethyl)thiazole is a useful synthetic intermediate used in the synthesis of Ritonavir (R535000)

Synthesis

To a 2-liter round bottomed flask equipped with a mechanical stirrer, thermometer and a condenser, whose outlet was vented into an aqueous sodium hydroxide trap, was charged the crude mixture of cis- and trans-3-chloropropenyl isothiocyanates (504.2 g, 3.79 mol) and chloroform (600 mL). The mixture was stirred and heated to reflux. Chlorine (267.1 g, 3.77 mole) gas was bubbled under the surface of the reaction over a period of 6-8 h. The conversion of the isothiocyanates to 2-chloro-5- (chloromethyl)thiazole was monitored by GC. When the reaction was shown to be complete by GC analysis, the reaction mixture was cooled and then filtered. The filtrate was concentrated on the rotary evaporator to remove chloroform. Sodium bicarbonate (approximately 0.25 equivalents) was added to the concentrated filtrate, and the product 2-chloro-5-chloromethylthiazole was distilled at 97 °C under vacuum (6mm/Hg). The yield after distillation was 43%. 1 H NMR (CDCl3) δ: 7.3 (s, 1H); 4.6 (s, 2H). 13C NMR (CDCl3) δ: 152.6 (C-2); 140.2 (C-4); 137.5 (C-5); 37.1 (-CH2-).

2-Chloro-5-chloromethylthiazole Preparation Products And Raw materials

Raw materials

Chloroform 2-chloro-3-isothiocyanato-prop-1-ene Sulfuryl chloride

Preparation Products

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2-Chloro-5-chloromethylthiazole Suppliers

Americas 1 China 369 Europe 2 Germany 6 India 4 Japan 3 Slovakia 1 Switzerland 1 Ukraine 1 United Kingdom 13 United States 27 Global 428

Jinan Junhe Pharmaceutical Co., Ltd

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J & K SCIENTIFIC LTD.

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INTATRADE GmbH

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3B Pharmachem (Wuhan) International Co.,Ltd.

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JinYan Chemicals(ShangHai) Co.,Ltd.

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Pure Chemistry Scientific Inc.

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View Lastest Price from 2-Chloro-5-chloromethylthiazole manufacturers

Hebei Weibang Biotechnology Co., Ltd

Product: 2-Chloro-5-chloromethylthiazole 105827-91-6
Price: US $30.00-10.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-24

Hebei Chuanghai Biotechnology Co,.LTD

Product: 2-Chloro-5-chloromethylthiazole 105827-91-6
Price: US $9.00/KG
Min. Order: 1KG
Purity: 99.9
Supply Ability: 1 ton
Release date: 2024-08-15

Hebei Mojin Biotechnology Co.,Ltd

Product: 2-CHLORO-5-CHLOROMETHYLTHIAZOLE 105827-91-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2024-05-22

105827-91-6, 2-Chloro-5-chloromethylthiazoleRelated Search:

4,6-Dichloropyrimidine 2-Chlorothiazole Chloromethane DIMETHYLTHEXYLSILYL CHLORIDE Metronidazole Dimethyl sulfone Nucleoside tert-Butyldimethylsilyl chloride 2-Methyl-4-isothiazolin-3-one 4-(Chloromethyl)benzoic acid Chloromethyl methyl ether Difluorochloromethane Thiamethoxam 5-Thiazolecarbonyl chloride, 2-chloro- (9CI) 5-CHLOROMETHYL-2,4-DICHLOROTHIAZOLE 2-Chloro-5-chloromethylthiazole 2-(4-BROMOPHENOXY)-4-CHLORO-5-CHLOROMETHYLTHIAZOLE 2-(3-CARBOXYPHENOXY)-4-CHLORO-5-CHLOROMETHYLTHIAZOLE

2-CHLORO-5-CHLOROMETHYLTHIAZOLE

2-CHLORO-5-CHLOROMETHYL-1,3-THIAZOLE

2-CHLORO-5-(CHLOROMETHYL)-1,3-THIAZOLE[FOR THIAMETHOXAM]

2-CHLORO-5-CHLOROMETHYL THIAZOLE, 98+%

2-chloro-5-(chloromethyl)thiozole

Thiazole, 2-chloro-5-(chloromethyl)- (9CI)

2-Chloro-5-(chlormethyl)thiazole

2-Chloro-5-chloromehtylthiazole

2-Chloro-5-Chloromethyl

ccmt

2-Chloro-5-chloromet

2-Chloro-5-thiazolylmethyl chloride

Thiazole,2-chloro-5-(chloroMethyl)-

2-Chloro-5-chl

2 Chloro 5 Chloro Methyl Thiazole(Ccmt)

2-Chloro-5-chloromethylthiazole 98%

oro-5-(chL

2-CHLORO-5-(CHLOROMETHYL)-THIAZOLE HYDROCHLORIDE

Clomethiazolum Impurity 4

105827-91-6

C4H3NSCl2

C4H3C12NS

C4H3Cl2NS

Thiazoles

Pesticide intermediate

HALOMETYL

Miscellaneous

API

bc0001

105827-91-6