2-Chloro-5-chloromethylthiazole
Description- Product Name
- 2-Chloro-5-chloromethylthiazole
- CAS No.
- 105827-91-6
- Chemical Name
- 2-Chloro-5-chloromethylthiazole
- Synonyms
- ccmt;2-CHLORO-5-CHLOROMETHYL-1,3-THIAZOLE;oro-5-(chL;2-Chloro-5-chl;2-Chloro-5-chloromet;2-Chloro-5-Chloromethyl;Clomethiazolum Impurity 4;2-CHLORO-5-CHLOROMETHYLTHIAZOLE;2-Chloro-5-chloromehtylthiazole;2-Chloro-5-(chlormethyl)thiazole
- CBNumber
- CB0366188
- Molecular Formula
- C4H3Cl2NS
- Formula Weight
- 168.04
- MOL File
- 105827-91-6.mol
2-Chloro-5-chloromethylthiazole Property
- Melting point:
- 31
- Boiling point:
- 268.6±32.0 °C(Predicted)
- Density
- 1.503±0.06 g/cm3(Predicted)
- refractive index
- n20/D1.571
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- soluble in Methanol
- pka
- 0.19±0.10(Predicted)
- color
- White to Light yellow
- BRN
- 5861439
- InChI
- InChI=1S/C4H3Cl2NS/c5-1-3-2-7-4(6)8-3/h2H,1H2
- InChIKey
- VRMUIVKEHJSADG-UHFFFAOYSA-N
- SMILES
- S1C(CCl)=CN=C1Cl
- CAS DataBase Reference
- 105827-91-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,N,T
- Risk Statements
- 36/37/38-51/53-43-34-24-22
- Safety Statements
- 26-37-61-45-36/37/39
- RIDADR
- 2922
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- 8
- PackingGroup
- Ⅱ
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H311Toxic in contact with skin
H314Causes severe skin burns and eye damage
H317May cause an allergic skin reaction
H411Toxic to aquatic life with long lasting effects
- Precautionary statements
-
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C3295
- Product name
- 2-Chloro-5-(chloromethyl)thiazole
- Packaging
- 5G
- Price
- $24
- Updated
- 2025/07/31
- Product number
- C3295
- Product name
- 2-Chloro-5-(chloromethyl)thiazole
- Packaging
- 25G
- Price
- $76
- Updated
- 2025/07/31
- Product number
- C367145
- Product name
- 2-Chloro-5-(chloromethyl)thiazole
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- C367145
- Product name
- 2-Chloro-5-(chloromethyl)thiazole
- Packaging
- 25g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- C367145
- Product name
- 2-Chloro-5-(chloromethyl)thiazole
- Packaging
- 50g
- Price
- $95
- Updated
- 2021/12/16
2-Chloro-5-chloromethylthiazole Chemical Properties,Usage,Production
Description
2-Chloro-5-chloromethylthiazole is used as pharmaceutical and agrochemical intermediate. It is also used as intermediate of insecticides Thiamethoxam and Clothianidin. It is also useful in in the synthesis of Ritonavir (R535000); a second-generation anti-AIDS drug and a selective HIV protease inhibitor.
Chemical Properties
White crystal or powder
Uses
2-Chloro-5-(chloromethyl)thiazole is a useful synthetic intermediate used in the synthesis of Ritonavir (R535000)
Synthesis
To a 2-liter round bottomed flask equipped with a mechanical stirrer, thermometer and a condenser, whose outlet was vented into an aqueous sodium hydroxide trap, was charged the crude mixture of cis- and trans-3-chloropropenyl isothiocyanates (504.2 g, 3.79 mol) and chloroform (600 mL). The mixture was stirred and heated to reflux. Chlorine (267.1 g, 3.77 mole) gas was bubbled under the surface of the reaction over a period of 6-8 h. The conversion of the isothiocyanates to 2-chloro-5- (chloromethyl)thiazole was monitored by GC. When the reaction was shown to be complete by GC analysis, the reaction mixture was cooled and then filtered. The filtrate was concentrated on the rotary evaporator to remove chloroform. Sodium bicarbonate (approximately 0.25 equivalents) was added to the concentrated filtrate, and the product 2-chloro-5-chloromethylthiazole was distilled at 97 °C under vacuum (6mm/Hg). The yield after distillation was 43%. 1 H NMR (CDCl3) δ: 7.3 (s, 1H); 4.6 (s, 2H). 13C NMR (CDCl3) δ: 152.6 (C-2); 140.2 (C-4); 137.5 (C-5); 37.1 (-CH2-).
References
[1] Patent: CN108484524, 2018, A. Location in patent: Paragraph 0051; 0052; 0053; 0054
[2] Patent: CN105294595, 2016, A. Location in patent: Paragraph 0013; 0014; 0015; 0016; 0017
[3] Journal of Agricultural and Food Chemistry, 2004, vol. 52, # 7, p. 1918 - 1922
[4] Patent: CN107935960, 2018, A. Location in patent: Paragraph 0031-0043
[5] Patent: CN105949145, 2016, A. Location in patent: Paragraph 0045; 0046
2-Chloro-5-chloromethylthiazole Preparation Products And Raw materials
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View Lastest Price from 2-Chloro-5-chloromethylthiazole manufacturers
- Product
- 2-Chloro-5-chloromethylthiazole 105827-91-6
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%min
- Supply Ability
- 20tons
- Release date
- 2025-08-27
- Product
- 2-Chloro-5-chloromethylthiazole 105827-91-6
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-24
- Product
- 2-Chloro-5-chloromethylthiazole 105827-91-6
- Price
- US $9.00/KG
- Min. Order
- 1KG
- Purity
- 99.9
- Supply Ability
- 1 ton
- Release date
- 2024-08-15