3-Hydroxy-3-methyl-2-butanone Chemical Properties

Melting point:

84-85 °C

Boiling point:

140-141 °C (lit.)

Density 

0.971 g/mL at 25 °C (lit.)

refractive index 

n20/D 1.415(lit.)

Flash point:

108 °F

storage temp. 

Flammables area

solubility 

Soluble in chloroform.

pka

13.28±0.29(Predicted)

form 

Liquid

color 

Clear colorless to yellow or light red

BRN 

1616385

InChIKey

BNDRWEVUODOUDW-UHFFFAOYSA-N

LogP

0.112 (est)

CAS DataBase Reference

115-22-0(CAS DataBase Reference)

EPA Substance Registry System

2-Butanone, 3-hydroxy-3-methyl- (115-22-0)

Safety Information

Risk Statements 

10

Safety Statements 

23-24/25-22

RIDADR 

UN 1224 3/PG 3

WGK Germany 

3

TSCA 

Yes

HazardClass 

3

PackingGroup 

III

HS Code 

29144000

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

3-Hydroxy-3-methyl-2-butanone Usage And Synthesis

Chemical Properties

CLEAR COLOURLESS TO LIGHT YELLOW LIQUID

Uses

3-Hydroxy-3-methyl-2-butanone used to produce 2,5-dihydroxy-2-methyl-heptan-3-one, laboratory chemicals.

Application

3-Hydroxy-3-methyl-2-butanone is an alpha-hydroxy ketone compound. It can be used as a biologically active natural product and a pharmaceutical intermediate, and as a photoinitiator in UV-curable coatings. At the same time, α-hydroxyketone structural units are also widely used synthons in organic synthesis. Hydroxyl can be used as a mild reaction precursor for double bonds, ester groups, carbonyl groups, halogenated hydrocarbons and other groups. Carbonyl can be used as the reaction precursor of hydroxyl, amino, alkyl and other groups. Therefore, α-hydroxyketone compounds are a class of compounds with important application value.

Preparation

synthesis of 3-Hydroxy-3-methyl-2-butanone: 19ml of concentrated sulfuric acid (98wt%) was slowly mixed with 100ml of water, then 13g of yellow mercury oxide was added within 1.5h, 84g (1.0mol) of 2-methyl-3-butyn-2-ol was added dropwise to the sulfuric acid solution containing mercury oxide at 65-75°C, Then the reaction was stirred at 65-75°C for 30min, cooled to room temperature after the reaction was completed, the reaction product was subjected to suction filtration, the filtrate after suction filtration was extracted with ether (3×20ml), and the organic phase after extraction was water and hydrogen carbonate respectively. Washed with sodium solution, the washed organic phase was dried with anhydrous magnesium sulfate, and then filtered, the filtered filtrate was concentrated by rotary evaporation and then distilled, and the 140°C fraction was collected, 45.6 g of light yellow liquid was obtained as 3-hydroxy-3-methyl-2-butanone, and the yield was 32.2%.

Definition

ChEBI: 3-Hydroxy-3-methylbutan-2-one is a secondary alpha-hydroxy ketone.

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