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TERT-BUTYLMALONONITRILE

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TERT-BUTYLMALONONITRILE Basic information

Product Name:
TERT-BUTYLMALONONITRILE
Synonyms:
  • RARECHEM AQ A3 0176
  • TERT-BUTYLMALONITRILE
  • TERT-BUTYLMALONONITRILE
  • 2-tert-butylmalononitrile
  • 2-tert-butylpropanedinitrile
  • tert-Butylmalononitrile
  • NISTC4210600
  • tert-Butylmalononitrile >
CAS:
4210-60-0
MF:
C7H10N2
MW:
122.17
Product Categories:
  • Dinitriles
  • Dinitriles & Trinitriles
Mol File:
4210-60-0.mol
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TERT-BUTYLMALONONITRILE Chemical Properties

Melting point:
84 °C
Boiling point:
80-85 °C(Press: 7 Torr)
Density 
0.930±0.06 g/cm3(Predicted)
solubility 
soluble in Methanol
form 
powder to crystaline
color 
White to Orange to Green
InChIKey
TUJPHMQZSDKRSL-UHFFFAOYSA-N
CAS DataBase Reference
4210-60-0
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Safety Information

Risk Statements 
23/24/25
Safety Statements 
26-36/37/39
RIDADR 
3276
HazardClass 
6.1
PackingGroup 
III
HS Code 
2926907090
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TERT-BUTYLMALONONITRILE Usage And Synthesis

Uses

TERT-BUTYLMALONONITRILE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis


The reaction was carried out under nitrogen. To the solution of aluminum chloride (14.5 g, 100 mmol) in 40 mL of nitromethane was added malonodinitrile 26 (6.6 g, 100 mmol). The temperature of the reaction mixture was kept between -15 and -20 °C, and tert-butyl bromide (22 g, 160 mmol) was added over a period of 30-45 min. The reaction mixture was allowed to warm to 0-5 °C and was maintained at that temperature. The reaction was monitored by TLC; the eluent was 30% EA/hexane. More tert-butyl bromide was added to complete the reaction. The reaction was worked up after 15 h by addition of a saturated solution of sodium bicarbonate to neutralize the HBr produced. The reaction mixture was extracted with methylene chloride. The organic layer was dried over anhydrous sodium sulfate and concentrated over vacuum. The 27 obtained (8.5 g, 70% yield) can be used for the next step without purification. t-Butylmalonodinitrile 27, yield (8.5 g, 70%) 1H NMR (300 MHz, CDCl3): δ 3.42(s, H), 1.24 (s, 9H).

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