Clemastine fumarate Chemical Properties

Melting point:

158-162°C

alpha 

D21 +16.9° (methanol)

Boiling point:

154°C (rough estimate)

Density 

1.0247 (rough estimate)

refractive index 

1.5790 (estimate)

storage temp. 

2-8°C

solubility 

DMSO: soluble5mg/mL (clear solution; warmed)

form 

powder

color 

white to beige

optical activity

[α]/D +15 to +25°, c = 1 in methanol

InChIKey

PMGQWSIVQFOFOQ-YKVZVUFRSA-N

CAS DataBase Reference

14976-57-9(CAS DataBase Reference)

Safety Information

WGK Germany 

3

RTECS 

UY0704600

HS Code 

2933992600

Hazardous Substances Data

14976-57-9(Hazardous Substances Data)

Toxicity

LD50 in mice, rats (mg/kg): 730, 3550 orally; 43, 82 i.v. (Weimann)

MSDS

• Language:English Provider:(2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine but-2-enedioic acid

Clemastine fumarate Usage And Synthesis

Chemical Properties

White Solid

Originator

Tavegyl,Sandoz,France,1967

Uses

anti-inflammatory

Uses

Clemastine fumarate is a selective histamine H1 receptor antagonist (Ki = 0.26 nM) that also displays high affinity for muscarinic receptors (Ki = 16 nM). It has also recently been identified as a positive allosteric modulator of P2X7 receptor signaling. Clemastine fumarate has long been used to inhibit histamine-induced bronchoconstriction in asthma and airway hyperresponsive studies.

Uses

H1 Histamine receptor antagonist. Antihistaminic.

Definition

ChEBI: The fumaric acid salt of clemastine. An antihistamine with antimuscarinic and moderate sedative properties, it is used for the symptomatic relief of allergic conditions such as rhinitis, urticaria, conjunctivitis and in pruritic (severe itching) skin condi ions.

Manufacturing Process

9.9 g of α-methyl-p-chlorobenzhydrol are added to a suspension of 2.3 g of powdered sodamide in 30 cc of benzene. Subsequently 7.4 g of Nmethylpyrrolidyl-(2)-ethyl chloride are added and the solution is heated to the boil at reflux for 20 hours. Then shaking is first effected with water and then 4 times each time with 25 cc of 2 N hydrochloric acid. The acid extracts are made alkaline with potassium hydroxide solution while cooling strongly, and the precipitated oil is extracted with ether. After drying of the ethereal solution over potassium carbonate, the solvent is evaporated and the residue is fractionally distilled in a high vacuum, whereby N-methyl-2-[2'-(α-methyl-pchlorobenzhydryloxy)-ethyl]-pyrrolidine boils over at 154°C/0.02 mm Hg. The base is converted to the fumarate by reaction with fumaric acid.

brand name

Tavist (Novartis).

Therapeutic Function

Antihistaminic

General Description

Dextrorotatory clemastine, R,R-2[2[1-(4-chlorophenyl)-1-phenylethoxy]ethyl]-1- methylpyrrolidine hydrogen furnarate (1:1) (Tavist), has two chiral centers, each of which has the (R) absolute configuration. A comparison of the activities of the enantiomers indicates that the asymmetric center close to the terminal side chain nitrogen is of lesser importance to antihistaminic activity.
? This member of the ethanolamine series is characterized by a long duration of action, with an activity that reaches a maximum in 5 to 7 hours and persists for 10 to 12 hours. It is well absorbed when administered orally, and it is excreted primarily in the urine. The side effects are those usually encountered with this series of antihistamines. Clemastine is closely related to chlorphenoxamine, which is used for its central cholinergic-blocking activity. Therefore, it is not surprising that clemastine has significant antimuscarinic activity.

Biological Activity

H 1 -receptor antagonist. Clinically-used antihistamine.

Biochem/physiol Actions

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.

Veterinary Drugs and Treatments

Clemastine may be used for symptomatic relief of histamine1-related allergic conditions.

storage

Store at RT

Clemastine fumarate(14976-57-9)Related Product Information

• Ethylparaben
• 2-Ethoxyphenol
• Ethoxyquin
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• Ethyl acetate
• Fumaric acid
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• 2-Ethoxyethanol
• 4-Ethoxyphenol
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• Dimethyl fumarate
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