4-Ethoxyphenol Chemical Properties

Melting point:

64-67 °C

Boiling point:

131 °C (9 mmHg)

Density 

1.0742 (rough estimate)

refractive index 

1.5231 (estimate)

FEMA 

3695 | HYDROQUINONE MONOETHYL ETHER

Flash point:

121°C/9mm

storage temp. 

Inert atmosphere,Room Temperature

solubility 

almost transparency in Methanol

form 

Crystalline Powder or Chunks

pka

10.44±0.13(Predicted)

color 

Beige

Odor

at 10.00 % in dipropylene glycol. mild hawthorn phenolic plastic nutty

Odor Type

animal

Water Solubility 

slightly soluble

JECFA Number

720

BRN 

1907114

InChIKey

LKVFCSWBKOVHAH-UHFFFAOYSA-N

LogP

1.87

CAS DataBase Reference

622-62-8(CAS DataBase Reference)

NIST Chemistry Reference

4-Ethoxyphenol(622-62-8)

EPA Substance Registry System

Phenol, 4-ethoxy- (622-62-8)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

41-37/38-22-36/37/38

Safety Statements 

37/39-26-36

WGK Germany 

3

RTECS 

SL3790000

TSCA 

Yes

HS Code 

29071990

MSDS

• Language:English Provider:4-Ethoxyphenol
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4-Ethoxyphenol Usage And Synthesis

Chemical Properties

beige crystalline powder or chunks

Chemical Properties

Hydroquinone monoethyl ether has a sweet herbaceous odor, which is reminiscent of anise and fennel

Uses

Intermediates of Liquid Crystals

Uses

4-Ethoxyphenol has been used as substrate to evaluate kinetic constant for the monophenolase activity of mushroom tyrosinase.

Definition

ChEBI: 4-Ethoxyphenol is a member of phenols and an aromatic ether.

Preparation

Hydroquinone monoethyl ether is produced by regulated (Mono)-ethylation of Hydroquinone with Diethylsulfate in weak aqueous alkaline solution.

Synthesis Reference(s)

Tetrahedron Letters, 35, p. 8727, 1994 DOI: 10.1016/S0040-4039(00)78482-6

General Description

4-Ethoxyphenol is the major dehalogenated product formed during H₂O₂-driven microperoxidase-8-catalyzed dehalogenation of 4-fluorophenol.

Safety Profile

Poison by intraperitoneal route. Experimentalreproductive effects. An irritant. When heated to decomposition it emits acrid smoke and irritating fumes.

Solubility in organics

Soluble in alcohol and oils. Fairly soluble in Propylene glycol.

4-Ethoxyphenol(622-62-8)Related Product Information

• Methylparaben
• Phenetidine
• 4-Hydroxyphenylacetic acid
• Ethoxyquin
• 4-Hydroxybenzyl alcohol
• 3-Hydroxybenzoic acid
• Phenetole
• 4-Ethylphenol
• 4-Hydroxy-D-(-)-2-phenylglycine
• Dimethyl ether
• DIETHOXYMETHANE
• Triclosan
• 2-Butoxyethanol
• 4-Cyanophenol
• 4-Methoxyphenol
• Ethoxyethyne
• Butylparaben
• Hydroquinone