MYXOTHIAZOL Chemical Properties

Boiling point:

679.6±65.0 °C(Predicted)

Density 

1.158±0.06 g/cm3(Predicted)

storage temp. 

-20°C

solubility 

chloroform: soluble9.80 - 10.20mg/mL, clear, colorless to yellow

form 

Solid

pka

14.07±0.50(Predicted)

color 

White to off-white

Safety Information

Hazard Codes 

T+

Risk Statements 

28

Safety Statements 

28-36/37-45

RIDADR 

UN 3462 6.1/PG 1

WGK Germany 

3

RTECS 

QH7580000

F 

10

HazardClass 

6.1(b)

PackingGroup 

III

MSDS

• Language:English Provider:SigmaAldrich

MYXOTHIAZOL Usage And Synthesis

Uses

Myxothiazol has been used in as a mitochondrial electron transport chain (mETC) inhibitor in P19 murine embryonal carcinoma pluripotent cell line and to treat HeLa cells for integrated stress response activation.

Definition

ChEBI: A 2,4'-bi-1,3-thiazole substituted at the 4-position with a (1E,3S,4R,5E)-7-amino-3,5-dimethoxy-4-methyl-7-oxohepta-1,5-dien-1-yl] group and at the 2'-position with a (2S

Biochem/physiol Actions

Myxothiazol, an antibiotic with activity against fungi and insects, is a strong inhibitor of mitochondrial cytochrome b/c1-segment of respiratory chain. Myxothiazol binds to the quinol oxidation (Qo) site of the bc1 complex, blocking electron transfer to the Rieske iron-sulfur protein in the mitochondrial respiratory chain. Oxygen consumption blockage leads to a cytostatic effect that could be reversed. Myxothiazol, as other Epothilones, which are known for their anti tumor activity, contains a thiazole ring that is formed by the incorporation of cysteine into the polyketide backbone.

MYXOTHIAZOL(76706-55-3)Related Product Information

• 2-Isopropyl-4-methyl thiazole
• 3-METHYL-1,5-HEPTADIENE
• 1,5-HEXADIEN-3-OL
• 2-Ethyl-4-methyl thiazole
• 4-METHYL-1-PENTEN-3-OL
• 2,4-Dimethylthiazole
• TRANS-2-METHYL-4-HEXEN-3-OL
• 2-isopropylthiazole
• 2-ETHYLTHIAZOLE
• 1,5-HEPTADIEN-4-OL
• 4-METHYL-1,5-HEPTADIENE
• MYXOTHIAZOL