VU 0409106
VU 0409106 Basic information
- Product Name:
- VU 0409106
- Synonyms:
-
- VU 0409106
- 3-Fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)benzamide
- Benzamide, 3-fluoro-N-(4-methyl-2-thiazolyl)-5-(5-pyrimidinyloxy)-
- 3-Fluoro-N-(4-methylthiazol-2-yl)-5-(pyrimidin-5-yloxy)benzamide
- CAS:
- 1276617-62-9
- MF:
- C15H11FN4O2S
- MW:
- 330.34
- Mol File:
- 1276617-62-9.mol
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VU 0409106 Chemical Properties
- Density
- 1.445±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 6.61±0.50(Predicted)
- color
- White to off-white
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VU 0409106 Usage And Synthesis
Uses
VU 0409106 is a novel negative allosteric modulator of metabotropic glutamate receptor subtype 5 (mGlu5). VU0409106 also was effective in a mouse marble burying anxiety behaviour.
in vivo
VU0409106 (10 mg/kg; i.p.; once) penetrates the blood-brain barrier (BBB) and demonstrates good brain to plasma ratio that near unity[1].
| Animal Model: | CD-1 mice[1] | ||||||||||||||||
| Dosage: | 10 mg/kg (10% Tween 80 formulation) | ||||||||||||||||
| Administration: | Intraperitoneal injection. | ||||||||||||||||
| Result: | 1.19Pharmacokinetic Parameters of VU0409106 in CD-1 mice[1].
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IC 50
mGlu5: 24 nM (IC50)
VU 0409106Supplier
Shanghaizehan biopharma technology co., Ltd.
- Tel
- 021-61350663 13052117465
- sales@zehanbiopharma.com
Shanghai Rechem science Co., Ltd.
- Tel
- 021-31433387 15618786686
- sales@rechemscience.com
Shanghai Hongye Biotechnology Co. Ltd
- Tel
- 400-9205774
- sales@glpbio.cn
BOC Sciences
- Tel
- info@bocsci.com
TargetMol Chemicals Inc.
- Tel
- 15002134094
- marketing@targetmol.cn