VU 0364439 Chemical Properties

Density 

1.538±0.06 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

≥21.11 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O

form 

solid

pka

7.71±0.10(Predicted)

VU 0364439 Usage And Synthesis

Uses

VU 0364439 is a mGlu4 positive allosteric modulator (PAM) (1,2).

References

[1]. lucyna pomierny-chamioło, kinga rup, bartosz pomierny, et al. metabotropic glutamatergic receptors and their ligands in drug addiction. pharmacology & therapeutics, 2014, 142:281-305.
[2]. albert j. robichaud, darren w. engers, craig w. lindsley, et al. recent progress on the identification of metabotropic glutamate 4 receptor ligands and their potential utility as cns therapeutics. acs chemical neuroscience, 2011, 2:433-449.
[3]. colleen m. niswender, kari a. johnson, c. david weaver, et al. discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. mol. pharmacol., 2008, 74(5):1345-1358.
[4]. darren w. engers, patrick r. gentry, richard williams, et al. synthesis and sar of novel, 4-(phenylsulfamoyl)phenylacetamide mglu4 positive allosteric modulators (pams) identified by functional high-throughput screening (hts). bioorg. med. chem. lett., 2010, 20:5175-5178.

VU 0364439(1246086-78-1)Related Product Information

• VU 0285683
• VU0155041
• N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide
• VU0134992(hydrochloride)
• VU6005649
• VU 591 hydrochloride
• VU0810464
• VU0483605
• N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide
• 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin
• VU 6008667
• (1R,2R)-N-([S]-1-{4-[5-broMo-2-oxo-2,3-dihydro-1H-benzo(d)iMidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxaMide
• 5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide
• 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine
• VU 0360172
• VU 0365114
• VU 0357121
• VU 0360223