VU6005649
VU6005649 Basic information
- Product Name:
- VU6005649
- Synonyms:
-
- VU6005649
- VU-6005649;VU 6005649
- VU6005649; VU-6005649; VU 6005649
- CS-2729
- Pyrazolo[1,5-a]pyrimidine, 3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)-
- Inhibitor,inhibit,VU6005649,mGluR,Metabotropic glutamate receptors,VU 6005649,VU-6005649
- 3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
- VU6005649, 10 mM in DMSO
- CAS:
- 2137047-43-7
- MF:
- C16H12F5N3O
- MW:
- 357.28
- Mol File:
- 2137047-43-7.mol
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VU6005649 Chemical Properties
- Density
- 1.43±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- pka
- -1.73±0.30(Predicted)
- form
- Solid
- color
- Light yellow to yellow
- InChI
- InChI=1S/C16H12F5N3O/c1-7-6-11(16(19,20)21)24-15(22-7)12(8(2)23-24)9-4-5-10(25-3)14(18)13(9)17/h4-6H,1-3H3
- InChIKey
- NYBZCKAQIIPSDS-UHFFFAOYSA-N
- SMILES
- C12=C(C3=CC=C(OC)C(F)=C3F)C(C)=NN1C(C(F)(F)F)=CC(C)=N2
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VU6005649 Usage And Synthesis
Uses
VU 6005649, is a novel mGlu7/8 receptor agonist with excellent CNS penetration (Kp 1.9-5.8 and Kp,uu 0.4-1.4).
in vivo
When VU6005649 (compound 9f) is dosed at 30 mg/kg IP in 10% Tween 80/H2O (0.75 mg/kg. s.c. amphetamine), no efficacy is observed in this assay. VU6005649 shows modest but significant pro-cognitive effects on associative learning in wild-type mice and the first example of efficacy of an mGlu7/8 positive allosteric modulator (PAM) in this model[1].
IC 50
mGlu7 Receptor: 0.65 μM (EC50); mGlu8 Receptor: 2.6 μM (EC50)
storage
Store at -20°C
VU6005649Supplier
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Shanghai Lollane Biological Technology Co.,Ltd.
- Tel
- 021-52996696，15000506266 15000506266
Shanghai Beckham Medical Technology Co., Ltd
- Tel
- 13816613772
- huahero21@sina.com
Shanghai EFE Biological Technology Co., Ltd.
- Tel
- 021-65675885 18964387627
- info@efebio.com
Shanghai YuanYe Biotechnology Co., Ltd.
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
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