ChemicalBook > CAS DataBase List > VU6005649

VU6005649

Product Name
VU6005649
CAS No.
2137047-43-7
Chemical Name
VU6005649
Synonyms
CS-2729;VU6005649;VU-6005649;VU 6005649;VU6005649, 10 mM in DMSO;VU6005649; VU-6005649; VU 6005649;Inhibitor,inhibit,VU6005649,mGluR,Metabotropic glutamate receptors,VU 6005649,VU-6005649;3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine;Pyrazolo[1,5-a]pyrimidine, 3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)-
CBNumber
CB73364461
Molecular Formula
C16H12F5N3O
Formula Weight
357.28
MOL File
2137047-43-7.mol
More
Less

VU6005649 Property

Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
pka
-1.73±0.30(Predicted)
form 
Solid
color 
Light yellow to yellow
InChI
InChI=1S/C16H12F5N3O/c1-7-6-11(16(19,20)21)24-15(22-7)12(8(2)23-24)9-4-5-10(25-3)14(18)13(9)17/h4-6H,1-3H3
InChIKey
NYBZCKAQIIPSDS-UHFFFAOYSA-N
SMILES
C12=C(C3=CC=C(OC)C(F)=C3F)C(C)=NN1C(C(F)(F)F)=CC(C)=N2
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Tocris
Product number
6893
Product name
VU6005649
Purity
≥98%(HPLC)
Packaging
50
Price
$655
Updated
2021/12/16
TRC
Product number
V850005
Product name
VU6005649
Packaging
1mg
Price
$685
Updated
2021/12/16
ChemScene
Product number
CS-0031100
Product name
VU6005649
Purity
98.67%
Packaging
100mg
Price
$1100
Updated
2021/12/16
ChemScene
Product number
CS-0031100
Product name
VU6005649
Purity
98.67%
Packaging
5mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0031100
Product name
VU6005649
Purity
98.67%
Packaging
10mg
Price
$150
Updated
2021/12/16
More
Less

VU6005649 Chemical Properties,Usage,Production

Uses

VU 6005649, is a novel mGlu7/8 receptor agonist with excellent CNS penetration (Kp 1.9-5.8 and Kp,uu 0.4-1.4).

in vivo

When VU6005649 (compound 9f) is dosed at 30 mg/kg IP in 10% Tween 80/H2O (0.75 mg/kg. s.c. amphetamine), no efficacy is observed in this assay. VU6005649 shows modest but significant pro-cognitive effects on associative learning in wild-type mice and the first example of efficacy of an mGlu7/8 positive allosteric modulator (PAM) in this model[1].

IC 50

mGlu7 Receptor: 0.65 μM (EC50); mGlu8 Receptor: 2.6 μM (EC50)

storage

Store at -20°C

VU6005649 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

VU6005649 Suppliers

China 35 United States 8 Global 43
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2391
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai SuperLan Chemcial Technique Centre
Tel
0-2022843681 15618226720
Fax
+86-21-51601218
Email
chaolaichem@foxmail.com
Country
China
ProdList
12475
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58

2137047-43-7, VU6005649Related Search:

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide VU0134992(hydrochloride) VU 591 hydrochloride VU0810464 VU0483605 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin VU 6008667 (1R,2R)-N-([S]-1-{4-[5-broMo-2-oxo-2,3-dihydro-1H-benzo(d)iMidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxaMide 5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine VU 0360172 VU 0365114 VU 0357121 VU 0360223 VU 0364439 VU0650786 VU0661013

  • VU6005649
  • VU-6005649;VU 6005649
  • VU6005649; VU-6005649; VU 6005649
  • CS-2729
  • Pyrazolo[1,5-a]pyrimidine, 3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)-
  • Inhibitor,inhibit,VU6005649,mGluR,Metabotropic glutamate receptors,VU 6005649,VU-6005649
  • 3-(2,3-difluoro-4-methoxyphenyl)-2,5-dimethyl-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine
  • VU6005649, 10 mM in DMSO
  • 2137047-43-7
  • C16H12F5N3O