VU0661013
- Product Name
- VU0661013
- CAS No.
- 2131184-57-9
- Chemical Name
- VU0661013
- Synonyms
- VU661013;VU0661013;1H-Indole-5-carboxylic acid, 3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-3,4-dihydro-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyrazino[1,2-a]indol-2(1H)-yl]-1-methyl-
- CBNumber
- CB04845069
- Molecular Formula
- C39H39Cl2N5O4
- Formula Weight
- 712.66
- MOL File
- 2131184-57-9.mol
VU0661013 Property
- Boiling point:
- 906.4±65.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥125mg/mL in DMSO;insoluble in H2O
- form
- Solid
- pka
- 4.44±0.30(Predicted)
- color
- Light yellow to yellow
N-Bromosuccinimide Price
- Product number
- A8783
- Product name
- VU661013
- Packaging
- 5mg
- Price
- $866
- Updated
- 2021/12/16
- Product number
- A8783
- Product name
- VU661013
- Packaging
- 10mg
- Price
- $1339
- Updated
- 2021/12/16
- Product number
- A8783
- Product name
- VU661013
- Packaging
- 25mg
- Price
- $2756
- Updated
- 2021/12/16
- Product number
- A8783
- Product name
- VU661013
- Packaging
- 50mg
- Price
- $4331
- Updated
- 2021/12/16
- Product number
- DC12064
- Product name
- VU0661013
- Purity
- >98%
- Packaging
- 1g
- Price
- $3600
- Updated
- 2021/12/16
VU0661013 Chemical Properties,Usage,Production
Biological Activity
vu661013 is a novel, potent, selective mcl-1 inhibitor (ki of 97 ± 30 pm).[1]mcl-1, an anti-apoptotic bcl-2 family member, is commonly upregulated in acute myeloblastic leukemia (aml) cells. targeting anti-apoptotic proteins in aml is a key therapeutic strategy, and mcl-1 is a critical anti-apoptotic oncoprotein. [1]vu661013 reduced expansion of multiple aml cell lines in vitro. venetoclax (a bcl-2 inhibitor) and vu661013 exhibited favorable synergy in several of aml cells lines, venetoclax-resistant aml cells were sensitive to vu661013. [1]vu661013 decreased tumor growth in an in vivo murine model. vu661013 (25mg/kg) and venetoclax (15mg/kg) can be synergistic in patient-derived xenograft transplantation models. [1][1]a novel mcl-1 inhibitor combined with venetoclax rescues venetoclax resistant acute myelogenous leukemia. cancer discov. 2018 sep 5. pmid: 30185627. doi: 10.1158/2159-8290.cd-18-0140
VU0661013 Preparation Products And Raw materials
Raw materials
Preparation Products
VU0661013 Suppliers
- Tel
- 021-52996696，15000506266 15000506266
- Fax
- +86-21-52996696
- Country
- China
- ProdList
- 4512
- Advantage
- 55
- Tel
- 021-65675885 18964387627
- Fax
- 021-65675885
- info@efebio.com
- Country
- China
- ProdList
- 9806
- Advantage
- 58
- Tel
- 177-54423994 17754423994
- Fax
- QQ:2853530913
- 2853530910@QQ.com
- Country
- China
- ProdList
- 8011
- Advantage
- 62
- Tel
- +86-13301875428
- sales@changyuhe.com
- Country
- China
- ProdList
- 305
- Advantage
- 58
- Tel
- 15911056312
- liming@bio-fount.com
- Country
- China
- ProdList
- 9729
- Advantage
- 58
- Tel
- +1-781-999-5354 +1-00000000000
- marketing@targetmol.com
- Country
- United States
- ProdList
- 32165
- Advantage
- 58
- Tel
- +1-708-310-1919 +1-13798911105
- Fax
- 708-557-7486
- sales@invivochem.cn
- Country
- United States
- ProdList
- 6391
- Advantage
- 58
- Tel
- 021-58447131 13564518121
- sales@dcchemicals.com
- Country
- China
- ProdList
- 9409
- Advantage
- 58
- Tel
- 18818260767
- Fax
- QQ 3610331285
- sales@chemegen.com
- Country
- China
- ProdList
- 11217
- Advantage
- 58
- Tel
- 88888888888
- hongquchem@qq.com
- Country
- China
- ProdList
- 5132
- Advantage
- 58