VU0661013
- Product Name
- VU0661013
- CAS No.
- 2131184-57-9
- Chemical Name
- VU0661013
- Synonyms
- VU661013;VU0661013;1H-Indole-5-carboxylic acid, 3-[(4R)-7-chloro-10-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-3,4-dihydro-4-methyl-1-oxo-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyrazino[1,2-a]indol-2(1H)-yl]-1-methyl-
- CBNumber
- CB04845069
- Molecular Formula
- C39H39Cl2N5O4
- Formula Weight
- 712.66
- MOL File
- 2131184-57-9.mol
VU0661013 Property
- Boiling point:
- 906.4±65.0 °C(Predicted)
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥125mg/mL in DMSO;insoluble in H2O
- pka
- 4.44±0.30(Predicted)
N-Bromosuccinimide Price
- Product number
- A8783
- Product name
- VU661013
- Packaging
- 5mg
- Price
- $866
- Updated
- 2021/12/16
- Product number
- A8783
- Product name
- VU661013
- Packaging
- 10mg
- Price
- $1339
- Updated
- 2021/12/16
- Product number
- A8783
- Product name
- VU661013
- Packaging
- 25mg
- Price
- $2756
- Updated
- 2021/12/16
- Product number
- A8783
- Product name
- VU661013
- Packaging
- 50mg
- Price
- $4331
- Updated
- 2021/12/16
- Product number
- DC12064
- Product name
- VU0661013
- Purity
- >98%
- Packaging
- 1g
- Price
- $3600
- Updated
- 2021/12/16
VU0661013 Chemical Properties,Usage,Production
Biological Activity
vu661013 is a novel, potent, selective mcl-1 inhibitor (ki of 97 ± 30 pm).[1]mcl-1, an anti-apoptotic bcl-2 family member, is commonly upregulated in acute myeloblastic leukemia (aml) cells. targeting anti-apoptotic proteins in aml is a key therapeutic strategy, and mcl-1 is a critical anti-apoptotic oncoprotein. [1]vu661013 reduced expansion of multiple aml cell lines in vitro. venetoclax (a bcl-2 inhibitor) and vu661013 exhibited favorable synergy in several of aml cells lines, venetoclax-resistant aml cells were sensitive to vu661013. [1]vu661013 decreased tumor growth in an in vivo murine model. vu661013 (25mg/kg) and venetoclax (15mg/kg) can be synergistic in patient-derived xenograft transplantation models. [1][1]a novel mcl-1 inhibitor combined with venetoclax rescues venetoclax resistant acute myelogenous leukemia. cancer discov. 2018 sep 5. pmid: 30185627. doi: 10.1158/2159-8290.cd-18-0140
VU0661013 Preparation Products And Raw materials
Raw materials
Preparation Products
VU0661013 Suppliers
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