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VU0810464

Product Name
VU0810464
CAS No.
2126040-21-7
Chemical Name
VU0810464
Synonyms
VU0810464;VU0810464, 10 mM in DMSO;2-(3-Chloro-4-fluorophenyl)-N-(1-cyclohexyl-3-methyl-1H-pyrazol-5-yl)acetamide;Benzeneacetamide, 3-chloro-N-(1-cyclohexyl-3-methyl-1H-pyrazol-5-yl)-4-fluoro-;3-?Chloro-?N-?(1-?cyclohexyl-?3-?methyl-?1H-?pyrazol-?5-?yl)?-?4-?fluoro-benzeneacetamide;cells,KcsA,VU-0810464,Potassium Channel,neuronal GIRK,HPC,VU0810464,VU 0810464,SAN,inhibit,Inhibitor
CBNumber
CB65839814
Molecular Formula
C18H21ClFN3O
Formula Weight
349.83
MOL File
2126040-21-7.mol
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VU0810464 Property

Boiling point:
549.1±50.0 °C(Predicted)
Density 
1.31±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥ 250 mg/mL (714.63 mM)
pka
13.35±0.70(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0093112
Product name
VU0810464
Purity
99.72%
Packaging
5mg
Price
$350
Updated
2021/12/16
ChemScene
Product number
CS-0093112
Product name
VU0810464
Purity
99.72%
Packaging
10mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0093112
Product name
VU0810464
Purity
99.72%
Packaging
50mg
Price
$1950
Updated
2021/12/16
Ambeed
Product number
A1219204
Product name
2-(3-Chloro-4-fluorophenyl)-N-(1-cyclohexyl-3-methyl-1H-pyrazol-5-yl)acetamide
Purity
98%
Packaging
100mg
Price
$438
Updated
2021/12/16
CSNpharm
Product number
CSN25285
Product name
VU0810464
Packaging
1mg
Price
$29
Updated
2021/12/16
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VU0810464 Chemical Properties,Usage,Production

Uses

VU0810464 is a potent and selective non-ureaG protein-gated inwardly-rectifying potassium channels (GIRK, Kir3) activator. VU0810464 displays nanomolar potency for neuronal (EC50=165 nM) and GIRK1/4 (EC50=720 nM) channels with improved brain penetration[1][2].

in vivo

VU0810464 (intraperitoneal?injection; 30 mg/kg, 10 mg/kg; 30mg/kg; pre-treated 30 mins) produces a dose-dependent reduction of SIH response in Male C57BL/6J mice. To test if VU0810464 plays it role through Kir3 channel activation, VU0810464 (10 mg/kg) suppresses the SIH response in wild‐ type mice, but has no impact on Kcnj3?/? mice[2]. VU0810464 (intraperitoneal?injection?; 30 mg/kg; 15, 30, 45, or 60 min post‐injection) displays a favourable distribution to the brain (Kp,uu = 0.83), has a improvement over ML297 (Kp,uu= 0.32). Clearance of VU0810464 is rapid,brain and plasma half-lives is 20 min in a PK study[2].

Animal Model:Male C57BL/6J mice, Kcnj3?/? siblings female and male C57BL/6J mice
Dosage:10 mg/kg; 30mg/kg
Administration:Intraperitoneal?injection
Result:Reduced stress‐induced hyperthermia (SIH), a physiological test of anxiolytic efficacy in wild mice, but had no impact in and Kcnj3 (Girk1) ?/? mice.

References

[1] Vo BN, et al. VU0810464, a non-urea G protein-gated inwardly rectifying K+?(Kir?3/GIRK) channel activator, exhibits enhanced selectivity for neuronal Kir?3 channels and reduces stress-induced hyperthermia in mice.Br J Pharmacol.?2019 Jul;176(13):2238-2249. DOI:10.1111/bph.14671
[2] Wieting JM,et al. Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators.ACS Chem Neurosci.?2017?Sep 20;8(9):1873-1879. DOI:10.1021/acschemneuro.7b00217

VU0810464 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU0810464 Suppliers

China 23 United States 4 Global 27
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
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2391
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55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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60
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
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55
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
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68
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
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58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
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58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
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10503
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58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
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58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55013243 15324716602
Email
2853979810@qq.com
Country
China
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9898
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58

2126040-21-7, VU0810464Related Search:

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide VU0134992(hydrochloride) VU6005649 VU 591 hydrochloride VU0483605 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin VU 6008667 (1R,2R)-N-([S]-1-{4-[5-broMo-2-oxo-2,3-dihydro-1H-benzo(d)iMidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxaMide 5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine VU 0360172 VU 0365114 VU 0357121 VU 0360223 VU 0364439 VU0650786 VU0661013

  • VU0810464
  • Benzeneacetamide, 3-chloro-N-(1-cyclohexyl-3-methyl-1H-pyrazol-5-yl)-4-fluoro-
  • 2-(3-Chloro-4-fluorophenyl)-N-(1-cyclohexyl-3-methyl-1H-pyrazol-5-yl)acetamide
  • cells,KcsA,VU-0810464,Potassium Channel,neuronal GIRK,HPC,VU0810464,VU 0810464,SAN,inhibit,Inhibitor
  • VU0810464, 10 mM in DMSO
  • 3-?Chloro-?N-?(1-?cyclohexyl-?3-?methyl-?1H-?pyrazol-?5-?yl)?-?4-?fluoro-benzeneacetamide
  • 2126040-21-7