ChemicalBook > CAS DataBase List > VU 6008667

VU 6008667

Product Name
VU 6008667
CAS No.
2092923-21-0
Chemical Name
VU 6008667
Synonyms
VU 6008667;5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-, (9bS)-
CBNumber
CB53364119
Molecular Formula
C24H17ClF2N2O2
Formula Weight
438.85
MOL File
2092923-21-0.mol
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VU 6008667 Property

Boiling point:
616.1±55.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 100 mg/mL (227.87 mM)
pka
-2.76±0.40(Predicted)
form 
Solid
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0021080
Product name
VU6008667
Purity
99.05%
Packaging
5mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0021080
Product name
VU6008667
Purity
99.05%
Packaging
10mg
Price
$330
Updated
2021/12/16
ChemScene
Product number
CS-0021080
Product name
VU6008667
Purity
99.05%
Packaging
25mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0021080
Product name
VU6008667
Purity
99.05%
Packaging
50mg
Price
$1350
Updated
2021/12/16
ChemScene
Product number
CS-0021080
Product name
VU6008667
Purity
99.05%
Packaging
100mg
Price
$2250
Updated
2021/12/16
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VU 6008667 Chemical Properties,Usage,Production

Uses

VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration[1].

in vivo

VU 6008667 (1 mg/kg)/PO (3 mg/kg, solution dose) displays a diminished elimination half-life (t1/2=2.3 hr) driven by a smaller volume (Vss=7.4 L/kg) and higher clearance (CLp=82 mL/min/kg), with moderate oral bioavailability (17% F)[1].

Animal Model:RAT (PK study)[1]
Dosage:1 mg/kg; 3 mg/kg
Administration:oral adminstration
Result:Had a desired short half-life in rat (t1/2= 2.3 hr), with moderate oral bioavailability (17% F).

IC 50

mAChR5

References

[1] McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359. DOI:10.1016/j.bmcl.2017.02.020

VU 6008667 Preparation Products And Raw materials

Raw materials

Preparation Products

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VU 6008667 Suppliers

China 14 United States 3 USA 1 Global 18
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ：2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58

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  • VU 6008667
  • 5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-, (9bS)-
  • 2092923-21-0