ChemicalBook > CAS DataBase List > VU 6008667

VU 6008667

Product Name
VU 6008667
CAS No.
2092923-21-0
Chemical Name
VU 6008667
Synonyms
VU 6008667;5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-, (9bS)-
CBNumber
CB53364119
Molecular Formula
C24H17ClF2N2O2
Formula Weight
438.85
MOL File
2092923-21-0.mol
More
Less

VU 6008667 Property

Boiling point:
616.1±55.0 °C(Predicted)
Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 100 mg/mL (227.87 mM)
pka
-2.76±0.40(Predicted)
form 
Solid
color 
Light yellow to yellow
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0021080
Product name
VU6008667
Purity
99.05%
Packaging
5mg
Price
$180
Updated
2021/12/16
ChemScene
Product number
CS-0021080
Product name
VU6008667
Purity
99.05%
Packaging
10mg
Price
$330
Updated
2021/12/16
ChemScene
Product number
CS-0021080
Product name
VU6008667
Purity
99.05%
Packaging
25mg
Price
$750
Updated
2021/12/16
ChemScene
Product number
CS-0021080
Product name
VU6008667
Purity
99.05%
Packaging
50mg
Price
$1350
Updated
2021/12/16
ChemScene
Product number
CS-0021080
Product name
VU6008667
Purity
99.05%
Packaging
100mg
Price
$2250
Updated
2021/12/16
More
Less

VU 6008667 Chemical Properties,Usage,Production

Uses

VU 6008667 is a selective negative allosteric modulator of M5 NAM with IC50s of 1.2 μM and 1.6 μM for human M5 and rat M5, respectively. High CNS penetration[1].

in vivo

VU 6008667 (1 mg/kg)/PO (3 mg/kg, solution dose) displays a diminished elimination half-life (t1/2=2.3 hr) driven by a smaller volume (Vss=7.4 L/kg) and higher clearance (CLp=82 mL/min/kg), with moderate oral bioavailability (17% F)[1].

Animal Model:RAT (PK study)[1]
Dosage:1 mg/kg; 3 mg/kg
Administration:oral adminstration
Result:Had a desired short half-life in rat (t1/2= 2.3 hr), with moderate oral bioavailability (17% F).

IC 50

mAChR5

References

[1] McGowan KM et al, Continued optimization of the M5 NAM ML375: Discovery of VU6008667, an M5 NAM with high CNS penetration and a desired short half-life in rat for addiction studies. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1356-1359. DOI:10.1016/j.bmcl.2017.02.020

VU 6008667 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

VU 6008667 Suppliers

China 14 United States 3 USA 1 Global 18
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9729
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Shanghai hongqu biomedical technology co. LTD
Tel
88888888888
Email
hongquchem@qq.com
Country
China
ProdList
5132
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 15801484223;
Email
psaitong@jm-bio.com
Country
China
ProdList
29757
Advantage
58
Kaifeng Mingren Pharmaceutical Co.,LTD
Tel
0371-65741762
Fax
QQ：2860768577
Email
sales@hasunny.com
Country
China
ProdList
2380
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Adooq Bioscience LLC
Tel
400-025-6535
Email
sales@adooq.cn
Country
China
ProdList
6215
Advantage
58
Guangzhou Jingyan Biotechnology Co., Ltd.
Tel
13822277471
Country
CHINA
ProdList
187
Advantage
58
Jinan Lemon Biotechnology Co., Ltd.
Tel
138000000
Email
geans@163.com
Country
China
ProdList
155
Advantage
58
Guangzhou Weisheng Biotechnology Co., Ltd.
Tel
17765667235
Country
CHINA
ProdList
129
Advantage
58
Tianjin Baibei Biotechnology Co., Ltd.
Tel
15302170631
Country
CHINA
ProdList
166
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6650
Advantage
58

2092923-21-0, VU 6008667Related Search:

N-(4-Methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide VU0134992(hydrochloride) VU6005649 VU 591 hydrochloride VU0810464 VU0483605 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin (1R,2R)-N-([S]-1-{4-[5-broMo-2-oxo-2,3-dihydro-1H-benzo(d)iMidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxaMide 5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine VU 0360172 VU 0365114 VU 0357121 VU 0360223 VU 0364439 VU0650786 VU0661013

  • VU 6008667
  • 5H-Imidazo[2,1-a]isoindol-5-one, 9b-(4-chloro-3-methylphenyl)-1-(3,4-difluorobenzoyl)-1,2,3,9b-tetrahydro-, (9bS)-
  • 2092923-21-0