VU0134992(hydrochloride)

Product Name: VU0134992(hydrochloride)
CAS No.: 1052515-91-9
Chemical Name: VU0134992(hydrochloride)
Synonyms: VU0134992 Hcl;VU0134992(hydrochloride);VU0134992 hydrochloride, 10 mM in DMSO;2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide hydrochloride;VU0134992,oral,hypertension,patch-clamp,electrophysiology,Kir4.1,VU 0134992,Inhibitor,natriuresis,inhibit,VU-0134992 hydrochloride,whole-cell,selective,kaliuresis,VU0134992 hydrochloride,Potassium Channel,KcsA,VU-0134992,diuresis
CBNumber: CB76187218
Molecular Formula: C20H32BrClN2O2
Formula Weight: 447.84
MOL File: 1052515-91-9.mol

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VU0134992(hydrochloride) Property

storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: 2mg/mL, clear
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2431
Product name: VU0134992 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $100
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML2431
Product name: VU0134992 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $406
Updated: 2025/07/31

ChemScene

Product number: CS-0114959
Product name: VU0134992 hydrochloride
Purity: 99.57%
Packaging: 100mg
Price: $650
Updated: 2021/12/16

ChemScene

Product number: CS-0114959
Product name: VU0134992 hydrochloride
Purity: 99.57%
Packaging: 10mg
Price: $125
Updated: 2021/12/16

ChemScene

Product number: CS-0114959
Product name: VU0134992 hydrochloride
Purity: 99.57%
Packaging: 5mg
Price: $70
Updated: 2021/12/16

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VU0134992(hydrochloride) Chemical Properties,Usage,Production

Uses

VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 μM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 μM) at -120 mV[1].

Biological Activity

VU0134992 is an orally available, potent and selective modulator of the inward rectifier potassium (Kir) channel Kir4.1 (KCNJ10) th at induces diuresis, natriuresis, and kaliuresis in rats.

in vivo

VU0134992 hydrochloride (50-100 mg/kg; oral gavage) statistically significantly increased urinary Na⁺ as well as K⁺ excretion^[1].

Animal Model:	Male Sprague-Dawley rats (250-300 g)^[1]
Dosage:	Oral gavage
Administration:	50 and 100 mg/kg
Result:	Statistically significantly increased urinary Na+ as well as K⁺ excretion.

References

[1] Kharade SV, et al. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937. DOI:10.1124/mol.118.112359

VU0134992(hydrochloride) Preparation Products And Raw materials

Raw materials

Preparation Products

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VU0134992(hydrochloride) Suppliers

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VU0134992(hydrochloride)

VU0134992,oral,hypertension,patch-clamp,electrophysiology,Kir4.1,VU 0134992,Inhibitor,natriuresis,inhibit,VU-0134992 hydrochloride,whole-cell,selective,kaliuresis,VU0134992 hydrochloride,Potassium Channel,KcsA,VU-0134992,diuresis

2-(2-Bromo-4-isopropylphenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)acetamide hydrochloride

VU0134992 hydrochloride, 10 mM in DMSO

VU0134992 Hcl

1052515-91-9