3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: 30mg/mL; DMF:PBS (pH 7.2) (1:4): 0.2mg/mL; DMSO: 20mg/mL; PBS (pH 7.2): insolube

form 

A crystalline solid

3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine Usage And Synthesis

Description

VU0029251 is a partial antagonist of metabotropic glutamate receptor 5 (mGluR5; K_i = 1.07 μM).¹ It inhibits calcium mobilization induced by glutamate in HEK293 cell membranes expressing rat mGluR5 (IC₅₀ = 1.7 μM).

References

1. Rodriguez, A.L., Grier, M.D., Jones, C.K., et al. Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity Mol. Pharmacol. 78(6),1105-1123(2010).

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