Propargyl-PEG5-Br Chemical Properties

Boiling point:

377.4±37.0 °C(Predicted)

Density 

1.247±0.06 g/cm3(Predicted)

Propargyl-PEG5-Br Usage And Synthesis

Biological Activity

Propargyl-PEG5-Br is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1009.

Propargyl-PEG5-Br(1287660-83-6)Related Product Information

• Propargyl-PEG5-methylamine
• 2-(2-Propynyloxy)ethylamine
• Proparyl-PEG5-methane