Beclin 1 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of proteins activated in response to nutrient deprivation and in neurodegenerative conditions. One of the proteins critical to this process is Beclin-1, the mammalian orthologue of the yeast autophagy protein Apg6/Vps30. Beclin-1 can complement defects in yeast autophagy caused by loss of Apg6 and can also stimulate autophagy when overexpressed in mammalian cells. Mammalian Beclin-1 was originally isolated in a yeast two-hybrid screen for Bcl-2 interacting proteins and has been shown to interact with Bcl-2 and Bcl-xL, but not with Bax or Bak. While Beclin-1 is generally ubiquitously expressed, research studies have shown it is monoallelically deleted in 40-75% of sporadic human breast and ovarian cancers. Beclin-1 is localized within cytoplasmic structures including the mitochondria, although overexpression of Beclin-1 reveals some nuclear staining and CRM1-dependent nuclear export. Investigators have demonstrated that Beclin-1-/- mice die early in embryogenesis and Beclin-1-/+ mice have a high incidence of spontaneous tumors. Stem cells from the null mice demonstrate an altered autophagic response, although responses to apoptosis appeared normal. Researchers have also found that overexpression of Beclin-1 in virally infected neurons in vivo resulted in significant protection against Sindbis virus-induced disease and neuronal apoptosis.

References

[1] Reggiori, F. and Klionsky, D.J. (2002) Eukaryot Cell 1, 11-21.
[2] Kametaka, S. et al. (1998) J Biol Chem 273, 22284-91.
[3] Liang, X.H. et al. (1999) Nature 402, 672-6.
[4] Liang, X.H. et al. (1998) J Virol 72, 8586-96.
[5] Aita, V.M. et al. (1999) Genomics 59, 59-65.
[6] Liang, X.H. et al. (2001) Cancer Res 61, 3443-9.
[7] Yue, Z. et al. (2003) Proc Natl Acad Sci USA 100, 15077-82.

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