EGR3 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Early growth response 3 is a zinc finger transcription factor and one of four members of the early growth response family. Members of this family are basally expressed in the brain and are immediate early response genes that are important for the induction of cellular programs of differentiation, proliferation, and cell death in response to environmental stimuli. EGR3 plays important roles in cellular growth and neuronal development and an essential role in learning and memory processing of both short- and long-term hippocampus-dependent memory; it also mediates adaptation to stress and novelty. Research studies show that a lack of EGR3 results in abnormal neuronal and T cell development.

References

[1] Kumbrink, J. et al. (2010) J Cell Biochem 111, 207-17.
[2] Kim, S.H. et al. (2010) Am J Med Genet B Neuropsychiatr Genet 153B, 1355-60.
[3] Zhang, R. et al. (2012) PLoS One 7, e30237.
[4] Suehiro, J. et al. (2010) Blood 115, 2520-32.

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