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BAY 11-7085

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BAY 11-7085 Basic information

Product Name:
BAY 11-7085
Synonyms:
  • BAY 117083 (2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
  • (2E)-3-[[4-(1,1-DIMETHYLETHYL)PHENYL]SULFONYL]-2-PROPENENITRILE
  • BAY 11-7085 - CAS 196309-76-9 - Calbiochem
  • CS-1876
  • BAY117085;BAY11-7085
  • BAY 11-7085;BAY-11-7085;BAY 11-7083
  • (E)-3-(T-BUTYLPHENYLSULFONYL)-2-PROPENENITRILE
  • (E)3-[(4-T-BUTYLPHENYL)SULFONYL]-2-PROPENENITRILE
CAS:
196309-76-9
MF:
C13H15NO2S
MW:
249.33
Product Categories:
  • Inhibitors
  • Cytokine signaling
Mol File:
196309-76-9.mol
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BAY 11-7085 Chemical Properties

Melting point:
80-82℃
Boiling point:
407.1±45.0 °C(Predicted)
Density 
1.144
Flash point:
200℃
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: >25 mg/mL, soluble
form 
solid
color 
white
Sensitive 
Light Sensitive
InChIKey
VHKZGNPOHPFPER-ONNFQVAWSA-N
CAS DataBase Reference
196309-76-9
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Safety Information

WGK Germany 
3
RTECS 
UD1312500
HS Code 
29309090

MSDS

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BAY 11-7085 Usage And Synthesis

Uses

In the classical pathway of NF-κB activation, phosphorylation of the inhibitor of NF-κB (IκBα) releases the inhibitor from NF-κB, allowing IκBα degradation and NF-κB activation and nuclear import. BAY-11-7085 is an irreversible inhibitor of IκBα phosphorylation, preventing activation of NF-κB by cytokines and lipopolysaccharide (IC50 = 10 μM). It blocks gene expression that is regulated through the classical pathway of NF-κB activation and in this way blocks apoptosis, cell adhesion, and inflammation. BAY-11-7085 is also used to study IκBα actions that are independent of NF-κB signaling.

Uses

Bay 11-7085 has been used as:

  • nuclear factor-κB inhibitor in Panc-1 cells, macrophages
  • inhibitory κB kinase IKK inhibitor in human astrocytoma cells U87MGs
  • phospho-p65 inhibitor human monocyte cell line THP-1

Definition

ChEBI: BAY11-7085 is a sulfone that is benzene substituted by [(E)-2-cyanoethenyl]sulfonyl and tert-butyl groups at position 1 and 4, respectively. It is an irreversible inhibitor of IkappaB-alpha phosphorylation in cells (IC50 = 10 muM) and prevents the activation of NF-kappaB. It has a role as an anti-inflammatory agent, a ferroptosis inducer, a NF-kappaB inhibitor, an apoptosis inducer, an autophagy inducer, an antibacterial agent, an EC 2.7.11.10 (IkappaB kinase) inhibitor and an antineoplastic agent. It is a nitrile, a sulfone and a member of benzenes.

Biological Activity

Irreversible inhibitor of TNF- α -stimulated I κ B α phosphorylation (IC 50 ~ 10 μ M); leads to decreased NF- κ B and subsequent decreased expression of adhesion molecules. Also reversibly activates MAP kinases and stimulates apoptosis. Anti-inflammatory in vivo .

Biochem/physiol Actions

Bay 11-7085 inactivates peroxisome proliferator-activated receptors γ (PPAR-γ) and increases the microtubule-associated proteins 1A/1B light chain 3B (LC3B), a marker of autophagy resulting in apoptosis in human synovial fibroblasts. It promotes apoptosis in pancreatic carcinoma and may serve as radiotherapy-sensitizing drug. BAY 11-7085 decreases B-cell lymphoma 2 (Bcl-2) by inhibiting pI-κBα (inhibitor of nuclear factor κ B kinase subunit α

storage

Store at +4°C

References

[1]nasu k1, nishida m, ueda t, yuge a, takai n, narahara h. application of the nuclear factor-kappab inhibitor bay 11-7085 for the treatment of endometriosis: an in vitro study. am j physiol endocrinol metab. 2007 jul;293(1):e16-23

BAY 11-7085Supplier

Shanghai Boyle Chemical Co., Ltd.
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3B Pharmachem (Wuhan) International Co.,Ltd.
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821-50328103-801 18930552037
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Chembest Research Laboratories Limited
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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Tetranov Biopharm
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13526569071
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sales@leadmedpharm.com