3-Fluoro-4-nitroanisole Chemical Properties

Melting point:

57.3

Boiling point:

264.5±20.0 °C(Predicted)

Density 

1.321±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,2-8°C

form 

crystalline solid

color 

Off-white

InChI

InChI=1S/C7H6FNO3/c1-12-5-2-3-7(9(10)11)6(8)4-5/h2-4H,1H3

InChIKey

PLEJCMKVJYUUBA-UHFFFAOYSA-N

SMILES

C1([N+]([O-])=O)=CC=C(OC)C=C1F

Safety Information

Hazard Codes 

Xi,C

Risk Statements 

34

Safety Statements 

26-36/37/39-45

RIDADR 

3261

Hazard Note 

Irritant/Keep Cold

HazardClass 

8

PackingGroup 

Ⅱ

HS Code 

2909309090

3-Fluoro-4-nitroanisole Usage And Synthesis

Uses

3-Fluoro-4-nitroanisole is synthesizing new antiseptic-germicide, sterilant, and the important organic fluoride-containing intermediate of liquid crystal material.

Synthesis

3-Fluoro-4-nitrophenol (75 g, 0.48 mol) was dissolved in acetone (700 mL) and cooled in an ice water bath. Subsequently, 1,8-diazabicyclo[5,4,0]undec-7-ene (145 g, 0.96 mol) was added slowly over about 1 hour and the reaction was held for 5 minutes. Next, iodomethane (135 g, 0.96 mol) was added dropwise over 10 min. The reaction mixture was stirred at room temperature for 16 hours. After that, 1,8-diazabicyclo[5,4,0]undec-7-ene (73 g, 0.48 mol) and iodomethane (68 g, 0.48 mol) were added and the mixture was heated to 50 °C and maintained for 1 hour. After completion of the reaction, the solid insoluble material was removed by filtration and the filtrate was concentrated and mixed with ethyl acetate and 1 M hydrochloric acid. The organic layer was washed sequentially with hydrochloric acid and aqueous sodium bicarbonate, concentrated and precipitated as a solid by stirring in a hexane solution of 1% ethyl acetate. Finally, the product 3-fluoro-4-nitroanisole (72 g, 88% yield) was collected and air dried.

References

[1] Chemistry - A European Journal, 2009, vol. 15, # 4, p. 885 - 900
[2] Chemistry - A European Journal, 2014, vol. 20, # 39, p. 12553 - 12558
[3] Patent: WO2004/76455, 2004, A1. Location in patent: Page 24
[4] Patent: US2007/232603, 2007, A1. Location in patent: Page/Page column 16
[5] Chemistry - A European Journal, 2013, vol. 19, # 29, p. 9599 - 9605

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