3-Fluoro-4-nitroanisole
- Product Name
- 3-Fluoro-4-nitroanisole
- CAS No.
- 446-38-8
- Chemical Name
- 3-Fluoro-4-nitroanisole
- Synonyms
- 2-Fluoro-4-methoxy-1-nitrobenzene;3-FLUORO-4-NITROANISOLE;Anisole, 3-fluoro-4-nitro-;3-Fluoro-4-nitroanisole 98%;2-Fluoro-4-methoxynitrobenzene;3-Fluor-4-nitrophenylmethylether;Benzene, 2-fluoro-4-methoxy-1-nitro-;2-FLUORO-4-(METHOXY-D3)-1-NITROBENZENE;5-Fluoro3-Fluoro-4-nitroanisole-2-nitrotoluene;2-Fluoro-4-methoxynitrobenzene[3-Fluoro-4-nitroanisole
- CBNumber
- CB0678203
- Molecular Formula
- C7H6FNO3
- Formula Weight
- 171.13
- MOL File
- 446-38-8.mol
3-Fluoro-4-nitroanisole Property
- Melting point:
- 57.3
- Boiling point:
- 264.5±20.0 °C(Predicted)
- Density
- 1.321±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- form
- crystalline solid
- color
- Off-white
- InChI
- InChI=1S/C7H6FNO3/c1-12-5-2-3-7(9(10)11)6(8)4-5/h2-4H,1H3
- InChIKey
- PLEJCMKVJYUUBA-UHFFFAOYSA-N
- SMILES
- C1([N+]([O-])=O)=CC=C(OC)C=C1F
Safety
- Hazard Codes
- Xi,C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- 3261
- WGK Germany
- WGK 3
- Hazard Note
- Irritant/Keep Cold
- HazardClass
- 8
- PackingGroup
- Ⅱ
- HS Code
- 2909309090
- Storage Class
- 8A - Combustible corrosive hazardous materials
- Hazard Classifications
- Aquatic Chronic 3
Eye Dam. 1
Skin Corr. 1B
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F1291
- Product name
- 2-Fluoro-4-methoxy-1-nitrobenzene
- Purity
- min. 98.0 %
- Packaging
- 5G
- Price
- $30
- Updated
- 2025/07/31
- Product number
- F1291
- Product name
- 2-Fluoro-4-methoxy-1-nitrobenzene
- Purity
- min. 98.0 %
- Packaging
- 25G
- Price
- $117
- Updated
- 2025/07/31
- Product number
- F597585
- Product name
- 3-Fluoro-4-nitroanisole
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- J94990
- Product name
- 3-Fluoro-4-nitroanisole
- Packaging
- 10g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- CS-D1687
- Product name
- Anisole,3-fluoro-4-nitro-
- Packaging
- 25g
- Price
- $50
- Updated
- 2021/12/16
3-Fluoro-4-nitroanisole Chemical Properties,Usage,Production
Uses
3-Fluoro-4-nitroanisole is synthesizing new antiseptic-germicide, sterilant, and the important organic fluoride-containing intermediate of liquid crystal material.
Synthesis
394-41-2
74-88-4
446-38-8
3-Fluoro-4-nitrophenol (75 g, 0.48 mol) was dissolved in acetone (700 mL) and cooled in an ice water bath. Subsequently, 1,8-diazabicyclo[5,4,0]undec-7-ene (145 g, 0.96 mol) was added slowly over about 1 hour and the reaction was held for 5 minutes. Next, iodomethane (135 g, 0.96 mol) was added dropwise over 10 min. The reaction mixture was stirred at room temperature for 16 hours. After that, 1,8-diazabicyclo[5,4,0]undec-7-ene (73 g, 0.48 mol) and iodomethane (68 g, 0.48 mol) were added and the mixture was heated to 50 °C and maintained for 1 hour. After completion of the reaction, the solid insoluble material was removed by filtration and the filtrate was concentrated and mixed with ethyl acetate and 1 M hydrochloric acid. The organic layer was washed sequentially with hydrochloric acid and aqueous sodium bicarbonate, concentrated and precipitated as a solid by stirring in a hexane solution of 1% ethyl acetate. Finally, the product 3-fluoro-4-nitroanisole (72 g, 88% yield) was collected and air dried.
References
[1] Chemistry - A European Journal, 2009, vol. 15, # 4, p. 885 - 900
[2] Chemistry - A European Journal, 2014, vol. 20, # 39, p. 12553 - 12558
[3] Patent: WO2004/76455, 2004, A1. Location in patent: Page 24
[4] Patent: US2007/232603, 2007, A1. Location in patent: Page/Page column 16
[5] Chemistry - A European Journal, 2013, vol. 19, # 29, p. 9599 - 9605
3-Fluoro-4-nitroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Fluoro-4-nitroanisole manufacturers
- Product
- 3-Fluoro-4-nitroanisole 446-38-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- Customise
- Release date
- 2025-08-19
- Product
- 3-Fluoro-4-nitroanisole 446-38-8
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000KGS
- Release date
- 2025-03-10
- Product
- 3-Fluoro-4-nitroanisole 446-38-8
- Price
- US $1.00-28.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20000KG
- Release date
- 2024-07-29