4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)CHLOROBENZENE Chemical Properties

Melting point:

50-55 °C(lit.)

Boiling point:

308.7±25.0 °C(Predicted)

Density 

1.10±0.1 g/cm3(Predicted)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

soluble in Methanol

form 

Solid

color 

White to pale brown

InChIKey

NYARTXMDWRAVIX-UHFFFAOYSA-N

CAS DataBase Reference

195062-61-4

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

Safety Statements 

36

WGK Germany 

3

HS Code 

2931900090

MSDS

• Language:English Provider:SigmaAldrich

4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)CHLOROBENZENE Usage And Synthesis

Uses

4-Chlorophenylboronic acid pinacol ester can be used as a reagent in Suzuki-Miyaura cross-coupling reaction to form C-C bonds by reacting with different aryl halides over palladium catalysts.
It can also be used as a reactant:

• To prepare 2-(4-chlorophenyl)-4H-chromen-4-one by treating with 4-chromanone via one-pot palladium-catalyzed dehydrogenation and oxidative boron-Heck coupling reaction.
• In the ligand-enabled C-H bond activation reaction in the presence of a palladium catalyst.
• To synthesize biaryl amides via Cu-catalyzed C-H bond coupling of aryl arylamides.

4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)CHLOROBENZENE(195062-61-4)Related Product Information

• 4-Chlorophenylboronic acid
• 2-(2-(Bromomethyl)-4-chlorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• 4-CHLORO-3-TRIFLUOROMETHYLPHENYLBORONIC ACID, PINACOL ESTER
• 4-CHLORO-3-NITROBENZENEBORONIC ACID, PINACOL ESTER 98
• 3-AMINO-4-CHLOROPHENYLBORONIC ACID, PINACOL ESTER
• 2,4-DICHLOROPHENYLBORONIC ACID, PINACOL ESTER
• 3,4-DICHLOROPHENYLBORONIC ACID, PINACOL ESTER
• 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)CHLOROBENZENE