Amyloid β-Protein (1-42) (mouse, rat)
Amyloid β-Protein (1-42) (mouse, rat) Basic information
- Product Name:
- Amyloid β-Protein (1-42) (mouse, rat)
- Synonyms:
-
- ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA
- ASP-ALA-GLU-PHE-GLY-HIS-ASP-SER-GLY-PHE-GLU-VAL-ARG-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-VAL-GLY-GLY-VAL-VAL-ILE-ALA
- BAP 1-42
- BETA-AMYLOID, SODIUM SALT
- Beta-Amyloid Peptide (1-42), mouse, rat
- AMyloid b-Protein (1-42) (Mouse, rat)
- PREDOMINANT AMYLOID B-PROTEIN FRAGMENT
- 767: PN: US20090175821 SEQID: 961 claimed protein
- CAS:
- 166090-74-0
- MF:
- C203H311N55O60S
- MW:
- 0
- Product Categories:
-
- peptide
- Neuroscience
- Mol File:
- Mol File
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Amyloid β-Protein (1-42) (mouse, rat) Chemical Properties
- storage temp.
- −20°C
- solubility
- Soluble in DMSO
- form
- Solid
- color
- White to off-white
- Sequence
- Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
MSDS
- Language:English Provider:SigmaAldrich
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Amyloid β-Protein (1-42) (mouse, rat) Usage And Synthesis
Uses
Substrate Cleavage Assays (30-100 μg/ml)
Biological Activity
Amyloid beta-peptide (1-42) (rat) is a 42 amino acid polypeptide that is toxic to hippocampal slices and can be used in Alzheimer's disease research.
in vivo
β-Amyloid (1-42), (rat/mouse) can induce Alzheimer's disease[4].
Induction of Alzheimer's disease[4]
Background
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder mainly characterized by the abnormal accumulation of β-amyloid (Aβ) peptide. The oligomeric form of the Aβ peptide as being the critical initiator of neurotoxicity in the AD pathogenesis[4].
Specific Modeling Methods
Rat: Wistar ? male ? adult, weighing 240-260 g
Administration: 1 μg/μL ? Hippocampal injection ? single dose
Administration: 1 μg/μL ? Hippocampal injection ? single dose
Note
(1) β-Amyloid (1-42) needs to be processed into oligomers before use.
(2) β-Amyloid (1-42) was injected bilaterally into the hippocampus of rat brain in a volume of 1.0 μL over a period of 0.1 μL/min using 1 μL Hamilton syringe.
(2) β-Amyloid (1-42) was injected bilaterally into the hippocampus of rat brain in a volume of 1.0 μL over a period of 0.1 μL/min using 1 μL Hamilton syringe.
Modeling Indicators
Indicator changes: Decreased the gene expression level of α7-nAChR and increased the mRNA expression of NMDA receptor 2A, and -2B subunits.
Behavior: β-Amyloid (1-42) aggregates increased the retention time and altered the behavioral response in rats after 15 days of injection.
Behavior: β-Amyloid (1-42) aggregates increased the retention time and altered the behavioral response in rats after 15 days of injection.
Correlated Product(s): β-Amyloid (1-42), (rat/mouse) TFA (HY-P1388A);
β-Amyloid (1-40) (rat) (HY-P1387);
β-Amyloid (1-40) TFA (HY-P0265A)
Opposite Product(s): /
target
Amyloid-beta
storage
Store at -20°C
Amyloid β-Protein (1-42) (mouse, rat)Supplier
Nanjing TGpeptide Biotechnology Co.,Ltd. Gold
- Tel
- 18115476705
- sales@tgpeptide.com
Hangzhou Sinoda Pharmaceutical Technology Co. LTD Gold
- Tel
- 0571-87213919 17306812703
- 3007955328@qq.com
QYAOBIO (ChinaPeptides CO., Ltd.) Gold
- Tel
- 021-50792271 18301728382
- cps041@chinapeptides.com
Shanghai YuanYe Biotechnology Co., Ltd. Gold
- Tel
- 021-61312847; 18021002903
- 3008007409@qq.com
3B Pharmachem (Wuhan) International Co.,Ltd.
- Tel
- 821-50328103-801 18930552037
- 3bsc@sina.com
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Amyloid β-Protein (1-42) (mouse, rat)(166090-74-0)Related Product Information
- AMYLOID BETA-PROTEIN (1-15)
- H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
- H-ILE-ILE-GLY-LEU-MET-OH
- AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE
- H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
- H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-OH
- H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH
- AMYLOID BETA-PROTEIN (29-40)
- Amyloid β-Peptide (1-42) (human)
- β-Amyloid Peptide (1-40), rat
- β-Amyloid Peptide (1-42), Hu 1PC x 0.25M
- β-Amyloid Peptide (1-42), Ra 1PC x 250UG
- β-Amyloid Peptide (1-40)